Mechanisms, Detection, and Potential Management of Microcirculatory Disturbances in Sepsis

Imran Mohammed, Stephanie Nonas

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Despite improvements in resuscitation and treatment of sepsis, the morbidity and mortality remain unacceptably high. Microvascular dysfunction has been shown to play a significant role in the pathogenesis of sepsis and is a potential new target in the management of sepsis. Clinical studies, aided by new techniques that allow for real-time assessment of the microcirculation, have shown that disturbances in microcirculatory flow are common in sepsis and correlate with worse outcomes. Bedside measurement of microcirculatory perfusion has become simpler and more accessible, and may provide key insights into prognosis in sepsis and guide future therapeutics, much like mean arterial pressure (MAP), lactate, and mixed central oxygen saturation (SvO2) do now. The authors review here the role of microcirculatory dysfunction in sepsis and its potential role as a therapeutic target in sepsis.

Original languageEnglish (US)
Pages (from-to)393-408
Number of pages16
JournalCritical Care Clinics
Volume26
Issue number2
DOIs
StatePublished - Apr 2010

Fingerprint

Sepsis
Microcirculation
Resuscitation
Lactic Acid
Arterial Pressure
Therapeutics
Perfusion
Oxygen
Morbidity
Mortality

Keywords

  • Microcirculatory disturbances
  • Microvascular blood flow
  • Microvascular perfusion
  • Sepsis

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Mechanisms, Detection, and Potential Management of Microcirculatory Disturbances in Sepsis. / Mohammed, Imran; Nonas, Stephanie.

In: Critical Care Clinics, Vol. 26, No. 2, 04.2010, p. 393-408.

Research output: Contribution to journalArticle

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