Mechanisms, Detection, and Potential Management of Microcirculatory Disturbances in Sepsis

Imran Mohammed, Stephanie A. Nonas

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Despite improvements in resuscitation and treatment of sepsis, the morbidity and mortality remain unacceptably high. Microvascular dysfunction has been shown to play a significant role in the pathogenesis of sepsis and is a potential new target in the management of sepsis. Clinical studies, aided by new techniques that allow for real-time assessment of the microcirculation, have shown that disturbances in microcirculatory flow are common in sepsis and correlate with worse outcomes. Bedside measurement of microcirculatory perfusion has become simpler and more accessible, and may provide key insights into prognosis in sepsis and guide future therapeutics, much like mean arterial pressure (MAP), lactate, and mixed central oxygen saturation (SvO2) do now. The authors review here the role of microcirculatory dysfunction in sepsis and its potential role as a therapeutic target in sepsis.

Original languageEnglish (US)
Pages (from-to)393-408
Number of pages16
JournalCritical Care Clinics
Issue number2
StatePublished - Apr 2010


  • Microcirculatory disturbances
  • Microvascular blood flow
  • Microvascular perfusion
  • Sepsis

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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