Mechanism of sequential induction of cell-type specific mRNAs in Dictyostelium differentiation

Rex L. Chisholm, Eric Barklis, Harvey F. Lodish

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Upon starvation, the cellular slime mould Dictyostelium discoideum initiates a 24-h programme of differentiation1. Within 6 h, cells move towards aggregation centres in response to pulsatile synthesis and secretion of cyclic AMP2-4. At about 12 h, aggregates of 10 5 cells are formed, held together by newly made surface adhesion molecules5-8. The cells then differentiate into the two principal types found in the terminal stage of development, spores and stalks. Here we show that the chemotaxis and aggregation stages of this developmental programme can be described as a series of sequential events in which these extracellular signals - starvation, cyclic AMP and cell-cell contact - induce specific, sequential changes in the pattern of gene expression.

Original languageEnglish (US)
Pages (from-to)67-69
Number of pages3
JournalNature
Volume310
Issue number5972
DOIs
StatePublished - 1984
Externally publishedYes

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Dictyostelium
Messenger RNA
Starvation
Dictyosteliida
Chemotaxis
Spores
Cyclic AMP
Gene Expression

ASJC Scopus subject areas

  • General

Cite this

Mechanism of sequential induction of cell-type specific mRNAs in Dictyostelium differentiation. / Chisholm, Rex L.; Barklis, Eric; Lodish, Harvey F.

In: Nature, Vol. 310, No. 5972, 1984, p. 67-69.

Research output: Contribution to journalArticle

Chisholm, Rex L. ; Barklis, Eric ; Lodish, Harvey F. / Mechanism of sequential induction of cell-type specific mRNAs in Dictyostelium differentiation. In: Nature. 1984 ; Vol. 310, No. 5972. pp. 67-69.
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