Mechanism of inducible regional dysfunction during dipyridamole stress

Jian Ping Bin, Dai-Trang (Elizabeth) Le, Robert A. Pelberg, Matthew P. Coggins, Kevin Wei, Sanjiv Kaul

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Background - We hypothesized that increased myocardial oxygen demand resulting from hypotension and reflex tachycardia unmasking a reduced endocardial myocardial blood flow (MBF) reserve is the mechanism of dipyridamole-induced regional dysfunction in chronic coronary artery disease. Methods and Results - Ameroid constrictors were placed around the proximal coronary arteries and their major branches in 15 dogs to create chronic coronary stenosis. Seven days later, radiolabeled microsphere-derived MBF and 2-dimensional echocardiography-derived percent wall thickening (%WT) were measured at rest and after 0.56 mg/kg dipyridamole. Dipyridamole caused an increase (mean, 21%) in the rate-pressure product secondary to reflex tachycardia resulting from mild systemic hypotension. %WT in myocardial segments with an endocardial MBF reserve (dipyridamole/resting MBF) of 1.5 to 2.5 (n=35) did not change after dipyridamole, whereas it decreased in segments with an endocardial MBF reserve of

Original languageEnglish (US)
Pages (from-to)112-117
Number of pages6
JournalCirculation
Volume106
Issue number1
DOIs
Publication statusPublished - Jul 1 2002
Externally publishedYes

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Keywords

  • Blood flow
  • Myocardium
  • Stress
  • Tachycardia

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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