Mechanism and clinical significance of prostaglandin-induced iris pigmentation

Johan W. Stjernschantz, Daniel M. Albert, Dan Ning Hu, Filippo Drago, Per J. Wistrand

Research output: Contribution to journalReview article

89 Scopus citations

Abstract

The new glaucoma drugs latanoprost, isopropyl unoprostone, travoprost, and bimatoprost cause increased pigmentation of the iris in some patients. The purpose of the present article is to survey the available preclinical and clinical data on prostaglandin-induced iris pigmentation and to assess the phenomenon from a clinical perspective. Most of the data have been obtained with latanoprost, and it appears that there is a predisposition to latanoprost-induced iris pigmentation in individuals with hazel or heterochromic eye color. As latanoprost and travoprost are selective agonists for the prostaglandin F receptor, it is likely that the phenomenon is mediated by this receptor. Several studies indicate that latanoprost stimulates melanogenesis in iridial melanocytes, and transcription of the tyrosinase gene is upregulated. The safety aspects of latanoprost-induced iris pigmentation have been addressed in histopathologic studies, and no evidence of harmful consequences of the side effect has been found. Although a final assessment of the clinical significance of prostaglandin-induced iris pigmentation currently is impossible to make, it appears that the only clear-cut disadvantage is a potential heterochromia between the eyes in unilaterally treated patients because the heterochromia is likely to be permanent, or very slowly reversible.

Original languageEnglish (US)
Pages (from-to)S162-S175
JournalSurvey of Ophthalmology
Volume47
Issue number4 SUPPL. 1
DOIs
StatePublished - Aug 1 2002

Keywords

  • Bimatoprost
  • Eye color
  • Glaucoma
  • Heterochromia
  • Iridial melanocytes
  • Isopropyl unoprostone
  • Latanoprost
  • Melanogenesis
  • Prostaglandin-induced iris pigmentation
  • Travoprost

ASJC Scopus subject areas

  • Ophthalmology

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