Mechanical endovascular recanalization therapies

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: The review compares recent trials using mechanical endovascular therapies with and without adjuvants to treat acute stroke. RECENT FINDINGS: The Multi Mechanical Embolus Removal in Cerebral Ischemia trial showed that good revascularization success could be obtained using the Merci retrievers within 8 h of symptom onset. In patients with persistent vascular occlusions despite intravenous tissue plasminogen activator, mechanical embolectomy appeared to be safe. The Interventional Management of Stroke II study achieved similar final revascularization success using low-dose tissue plasminogen activator within 3 h of symptom onset followed by intra-arterial tissue plasminogen activator or EKOS ultrasound plus intra-arterial tissue plasminogen activator. In these trials, patients with recanalization had better outcomes than those without revascularization. Effects of trial design, such as time to treatment, patient age, and use of adjuvant therapies, may affect outcomes. SUMMARY: Recent trials of mechanical endovascular therapies have shown recanalization in the majority of target vessels and better outcomes in those patients in whom recanalization was achieved than in those without recanalization. Differences in trial design and lack of head to head comparisons to date make it difficult to determine whether one treatment approach is better than another.

Original languageEnglish (US)
Pages (from-to)70-75
Number of pages6
JournalCurrent Opinion in Neurology
Volume21
Issue number1
DOIs
StatePublished - Feb 2008

Fingerprint

Tissue Plasminogen Activator
Stroke
Embolectomy
Therapeutics
Embolism
Brain Ischemia
Blood Vessels

Keywords

  • Acute stroke treatment
  • Device
  • Intra-arterial
  • Mechanical thrombectomy
  • Merci retriever
  • Stroke

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Mechanical endovascular recanalization therapies. / Lutsep, Helmi.

In: Current Opinion in Neurology, Vol. 21, No. 1, 02.2008, p. 70-75.

Research output: Contribution to journalArticle

@article{151a895fba0c4e93b78d82cb76ca80b1,
title = "Mechanical endovascular recanalization therapies",
abstract = "PURPOSE OF REVIEW: The review compares recent trials using mechanical endovascular therapies with and without adjuvants to treat acute stroke. RECENT FINDINGS: The Multi Mechanical Embolus Removal in Cerebral Ischemia trial showed that good revascularization success could be obtained using the Merci retrievers within 8 h of symptom onset. In patients with persistent vascular occlusions despite intravenous tissue plasminogen activator, mechanical embolectomy appeared to be safe. The Interventional Management of Stroke II study achieved similar final revascularization success using low-dose tissue plasminogen activator within 3 h of symptom onset followed by intra-arterial tissue plasminogen activator or EKOS ultrasound plus intra-arterial tissue plasminogen activator. In these trials, patients with recanalization had better outcomes than those without revascularization. Effects of trial design, such as time to treatment, patient age, and use of adjuvant therapies, may affect outcomes. SUMMARY: Recent trials of mechanical endovascular therapies have shown recanalization in the majority of target vessels and better outcomes in those patients in whom recanalization was achieved than in those without recanalization. Differences in trial design and lack of head to head comparisons to date make it difficult to determine whether one treatment approach is better than another.",
keywords = "Acute stroke treatment, Device, Intra-arterial, Mechanical thrombectomy, Merci retriever, Stroke",
author = "Helmi Lutsep",
year = "2008",
month = "2",
doi = "10.1097/WCO.0b013e3282f35564",
language = "English (US)",
volume = "21",
pages = "70--75",
journal = "Current Opinion in Neurology",
issn = "1350-7540",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Mechanical endovascular recanalization therapies

AU - Lutsep, Helmi

PY - 2008/2

Y1 - 2008/2

N2 - PURPOSE OF REVIEW: The review compares recent trials using mechanical endovascular therapies with and without adjuvants to treat acute stroke. RECENT FINDINGS: The Multi Mechanical Embolus Removal in Cerebral Ischemia trial showed that good revascularization success could be obtained using the Merci retrievers within 8 h of symptom onset. In patients with persistent vascular occlusions despite intravenous tissue plasminogen activator, mechanical embolectomy appeared to be safe. The Interventional Management of Stroke II study achieved similar final revascularization success using low-dose tissue plasminogen activator within 3 h of symptom onset followed by intra-arterial tissue plasminogen activator or EKOS ultrasound plus intra-arterial tissue plasminogen activator. In these trials, patients with recanalization had better outcomes than those without revascularization. Effects of trial design, such as time to treatment, patient age, and use of adjuvant therapies, may affect outcomes. SUMMARY: Recent trials of mechanical endovascular therapies have shown recanalization in the majority of target vessels and better outcomes in those patients in whom recanalization was achieved than in those without recanalization. Differences in trial design and lack of head to head comparisons to date make it difficult to determine whether one treatment approach is better than another.

AB - PURPOSE OF REVIEW: The review compares recent trials using mechanical endovascular therapies with and without adjuvants to treat acute stroke. RECENT FINDINGS: The Multi Mechanical Embolus Removal in Cerebral Ischemia trial showed that good revascularization success could be obtained using the Merci retrievers within 8 h of symptom onset. In patients with persistent vascular occlusions despite intravenous tissue plasminogen activator, mechanical embolectomy appeared to be safe. The Interventional Management of Stroke II study achieved similar final revascularization success using low-dose tissue plasminogen activator within 3 h of symptom onset followed by intra-arterial tissue plasminogen activator or EKOS ultrasound plus intra-arterial tissue plasminogen activator. In these trials, patients with recanalization had better outcomes than those without revascularization. Effects of trial design, such as time to treatment, patient age, and use of adjuvant therapies, may affect outcomes. SUMMARY: Recent trials of mechanical endovascular therapies have shown recanalization in the majority of target vessels and better outcomes in those patients in whom recanalization was achieved than in those without recanalization. Differences in trial design and lack of head to head comparisons to date make it difficult to determine whether one treatment approach is better than another.

KW - Acute stroke treatment

KW - Device

KW - Intra-arterial

KW - Mechanical thrombectomy

KW - Merci retriever

KW - Stroke

UR - http://www.scopus.com/inward/record.url?scp=37849034836&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=37849034836&partnerID=8YFLogxK

U2 - 10.1097/WCO.0b013e3282f35564

DO - 10.1097/WCO.0b013e3282f35564

M3 - Article

C2 - 18180654

AN - SCOPUS:37849034836

VL - 21

SP - 70

EP - 75

JO - Current Opinion in Neurology

JF - Current Opinion in Neurology

SN - 1350-7540

IS - 1

ER -