Measuring cone density in a Japanese macaque (Macaca fuscata) model of age-related macular degeneration with commercially available adaptive optics

Mark E. Pennesi; Anupam K. Garg; Shu Feng; Keith V. Michaels; Travis B. Smith; Jonathan D. Fay; Alison R. Weiss; Laurie M. Renner; Sawan Hurst; Trevor J. McGill; Anda Cornea; Kay D. Rittenhouse; Marvin Sperling; Joachim Fruebis; Martha Neuringer

doi:10.1007/978-1-4614-3209-8_39

Measuring cone density in a Japanese macaque (Macaca fuscata) model of age-related macular degeneration with commercially available adaptive optics

Mark E. Pennesi, Anupam K. Garg, Shu Feng, Keith V. Michaels, Travis B. Smith, Jonathan D. Fay, Alison R. Weiss, Laurie M. Renner, Sawan Hurst, Trevor J. McGill, Anda Cornea, Kay D. Rittenhouse, Marvin Sperling, Joachim Fruebis, Martha Neuringer

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7 Scopus citations

Abstract

The aim of this study was to assess the feasibility of using a commercially available high-resolution adaptive optics (AO) camera to image the cone mosaic in Japanese macaques (Macaca fuscata) with dominantly inherited drusen. The macaques examined develop drusen closely resembling those seen in humans with age-related macular degeneration (AMD). For each animal, we acquired and processed images from the AO camera, montaged the results into a composite image, applied custom cone-counting software to detect individual cone photoreceptors, and created a cone density map of the macular region. We conclude that flood-illuminated AO provides a promising method of visualizing the cone mosaic in nonhuman primates. Future studies will quantify the longitudinal change in the cone mosaic and its relationship to the severity of drusen in these animals.

Original language	English (US)
Pages (from-to)	309-316
Number of pages	8
Journal	Advances in experimental medicine and biology
Volume	801
DOIs	https://doi.org/10.1007/978-1-4614-3209-8_39
State	Published - 2014

Keywords

AMD
Adaptive optics
Cone density imaging
Flood-illuminated adaptive optics

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/978-1-4614-3209-8_39

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Pennesi, M. E., Garg, A. K., Feng, S., Michaels, K. V., Smith, T. B., Fay, J. D., Weiss, A. R., Renner, L. M., Hurst, S., McGill, T. J., Cornea, A., Rittenhouse, K. D., Sperling, M., Fruebis, J., & Neuringer, M. (2014). Measuring cone density in a Japanese macaque (Macaca fuscata) model of age-related macular degeneration with commercially available adaptive optics. Advances in experimental medicine and biology, 801, 309-316. https://doi.org/10.1007/978-1-4614-3209-8_39

Pennesi, ME, Garg, AK, Feng, S, Michaels, KV, Smith, TB, Fay, JD, Weiss, AR, Renner, LM, Hurst, S, McGill, TJ, Cornea, A, Rittenhouse, KD, Sperling, M, Fruebis, J & Neuringer, M 2014, 'Measuring cone density in a Japanese macaque (Macaca fuscata) model of age-related macular degeneration with commercially available adaptive optics', Advances in experimental medicine and biology, vol. 801, pp. 309-316. https://doi.org/10.1007/978-1-4614-3209-8_39

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title = "Measuring cone density in a Japanese macaque (Macaca fuscata) model of age-related macular degeneration with commercially available adaptive optics",

abstract = "The aim of this study was to assess the feasibility of using a commercially available high-resolution adaptive optics (AO) camera to image the cone mosaic in Japanese macaques (Macaca fuscata) with dominantly inherited drusen. The macaques examined develop drusen closely resembling those seen in humans with age-related macular degeneration (AMD). For each animal, we acquired and processed images from the AO camera, montaged the results into a composite image, applied custom cone-counting software to detect individual cone photoreceptors, and created a cone density map of the macular region. We conclude that flood-illuminated AO provides a promising method of visualizing the cone mosaic in nonhuman primates. Future studies will quantify the longitudinal change in the cone mosaic and its relationship to the severity of drusen in these animals.",

keywords = "AMD, Adaptive optics, Cone density imaging, Flood-illuminated adaptive optics",

author = "Pennesi, {Mark E.} and Garg, {Anupam K.} and Shu Feng and Michaels, {Keith V.} and Smith, {Travis B.} and Fay, {Jonathan D.} and Weiss, {Alison R.} and Renner, {Laurie M.} and Sawan Hurst and McGill, {Trevor J.} and Anda Cornea and Rittenhouse, {Kay D.} and Marvin Sperling and Joachim Fruebis and Martha Neuringer",

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year = "2014",

doi = "10.1007/978-1-4614-3209-8_39",

language = "English (US)",

volume = "801",

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AU - Pennesi, Mark E.

AU - Garg, Anupam K.

AU - Feng, Shu

AU - Michaels, Keith V.

AU - Smith, Travis B.

AU - Fay, Jonathan D.

AU - Weiss, Alison R.

AU - Renner, Laurie M.

AU - Hurst, Sawan

AU - McGill, Trevor J.

AU - Cornea, Anda

AU - Rittenhouse, Kay D.

AU - Sperling, Marvin

AU - Fruebis, Joachim

AU - Neuringer, Martha

PY - 2014

Y1 - 2014

N2 - The aim of this study was to assess the feasibility of using a commercially available high-resolution adaptive optics (AO) camera to image the cone mosaic in Japanese macaques (Macaca fuscata) with dominantly inherited drusen. The macaques examined develop drusen closely resembling those seen in humans with age-related macular degeneration (AMD). For each animal, we acquired and processed images from the AO camera, montaged the results into a composite image, applied custom cone-counting software to detect individual cone photoreceptors, and created a cone density map of the macular region. We conclude that flood-illuminated AO provides a promising method of visualizing the cone mosaic in nonhuman primates. Future studies will quantify the longitudinal change in the cone mosaic and its relationship to the severity of drusen in these animals.

AB - The aim of this study was to assess the feasibility of using a commercially available high-resolution adaptive optics (AO) camera to image the cone mosaic in Japanese macaques (Macaca fuscata) with dominantly inherited drusen. The macaques examined develop drusen closely resembling those seen in humans with age-related macular degeneration (AMD). For each animal, we acquired and processed images from the AO camera, montaged the results into a composite image, applied custom cone-counting software to detect individual cone photoreceptors, and created a cone density map of the macular region. We conclude that flood-illuminated AO provides a promising method of visualizing the cone mosaic in nonhuman primates. Future studies will quantify the longitudinal change in the cone mosaic and its relationship to the severity of drusen in these animals.

KW - AMD

KW - Adaptive optics

KW - Cone density imaging

KW - Flood-illuminated adaptive optics

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Measuring cone density in a Japanese macaque (Macaca fuscata) model of age-related macular degeneration with commercially available adaptive optics

Abstract

Keywords

ASJC Scopus subject areas

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