Measuring cone density in a Japanese macaque (Macaca fuscata) model of age-related macular degeneration with commercially available adaptive optics

Mark E. Pennesi, Anupam K. Garg, Shu Feng, Keith V. Michaels, Travis B. Smith, Jonathan D. Fay, Alison R. Weiss, Laurie M. Renner, Sawan Hurst, Trevor J. McGill, Anda Cornea, Kay D. Rittenhouse, Marvin Sperling, Joachim Fruebis, Martha Neuringer

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The aim of this study was to assess the feasibility of using a commercially available high-resolution adaptive optics (AO) camera to image the cone mosaic in Japanese macaques (Macaca fuscata) with dominantly inherited drusen. The macaques examined develop drusen closely resembling those seen in humans with age-related macular degeneration (AMD). For each animal, we acquired and processed images from the AO camera, montaged the results into a composite image, applied custom cone-counting software to detect individual cone photoreceptors, and created a cone density map of the macular region. We conclude that flood-illuminated AO provides a promising method of visualizing the cone mosaic in nonhuman primates. Future studies will quantify the longitudinal change in the cone mosaic and its relationship to the severity of drusen in these animals.

Original languageEnglish (US)
Pages (from-to)309-316
Number of pages8
JournalAdvances in experimental medicine and biology
Volume801
DOIs
StatePublished - Jan 1 2014

Keywords

  • AMD
  • Adaptive optics
  • Cone density imaging
  • Flood-illuminated adaptive optics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Pennesi, M. E., Garg, A. K., Feng, S., Michaels, K. V., Smith, T. B., Fay, J. D., Weiss, A. R., Renner, L. M., Hurst, S., McGill, T. J., Cornea, A., Rittenhouse, K. D., Sperling, M., Fruebis, J., & Neuringer, M. (2014). Measuring cone density in a Japanese macaque (Macaca fuscata) model of age-related macular degeneration with commercially available adaptive optics. Advances in experimental medicine and biology, 801, 309-316. https://doi.org/10.1007/978-1-4614-3209-8_39