Measuring age-related changes in dopamine D2 receptors with 11C-raclopride and 18F-N-methylspiroperidol

Nora D. Volkow; Gene Jack Wang; Joanna S. Fowler; Jean Logan; Samuel J. Gatley; Robert R. MacGregor; David J. Schlyer; Robert Hitzemann; Alfred P. Wolf

doi:10.1016/0925-4927(96)02809-0

Measuring age-related changes in dopamine D₂ receptors with ¹¹C-raclopride and ¹⁸F-N-methylspiroperidol

Nora D. Volkow, Gene Jack Wang, Joanna S. Fowler, Jean Logan, Samuel J. Gatley, Robert R. MacGregor, David J. Schlyer, Robert Hitzemann, Alfred P. Wolf

Research output: Contribution to journal › Article › peer-review

131 Scopus citations

Abstract

This study investigates the rate of age-related dopamine D2 receptor loss as determined by positron emission tomography (PET) and ¹¹C-raclopride and compares it with D₂ loss previously estimated with ¹⁸F-N-methylspiroperidol (NMS). Dopamine D2 receptors were measured with ¹¹C-raclopride in 24 healthy volunteers (24-73 years of age) using the ratio of the distribution volume in striatum to that in cerebellum (B_max/K_d + 1). The results were compared with those obtained in 20 healthy male volunteers (20-49 years of age) in whom D₂ receptors were measured with NMS using the ratio index (slope of the striatum-to-cerebellum ratio as a function of time). Findings of correlational analysis between age and dopamine D₂ receptor availability were significant for both ligands. Estimates of dopamine D₂ receptor loss per decade corresponded to 7.9% for the ¹¹C-raclopride study and 7.8% for the NMS study. Both ligands documented significant age-related decreases in dopamine D₂ receptors that occurred relatively early in life (40 years of age).

Original language	English (US)
Pages (from-to)	11-16
Number of pages	6
Journal	Psychiatry Research - Neuroimaging
Volume	67
Issue number	1
DOIs	https://doi.org/10.1016/0925-4927(96)02809-0
State	Published - May 31 1996
Externally published	Yes

Keywords

Aging
Neurodegeneration
Positron emission tomography
Striatum

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Radiology Nuclear Medicine and imaging
Psychiatry and Mental health

Access to Document

10.1016/0925-4927(96)02809-0

Cite this

@article{77e6a19b3b454155b84118ce8df886b1,

title = "Measuring age-related changes in dopamine D2 receptors with 11C-raclopride and 18F-N-methylspiroperidol",

abstract = "This study investigates the rate of age-related dopamine D2 receptor loss as determined by positron emission tomography (PET) and 11C-raclopride and compares it with D2 loss previously estimated with 18F-N-methylspiroperidol (NMS). Dopamine D2 receptors were measured with 11C-raclopride in 24 healthy volunteers (24-73 years of age) using the ratio of the distribution volume in striatum to that in cerebellum (Bmax/Kd + 1). The results were compared with those obtained in 20 healthy male volunteers (20-49 years of age) in whom D2 receptors were measured with NMS using the ratio index (slope of the striatum-to-cerebellum ratio as a function of time). Findings of correlational analysis between age and dopamine D2 receptor availability were significant for both ligands. Estimates of dopamine D2 receptor loss per decade corresponded to 7.9% for the 11C-raclopride study and 7.8% for the NMS study. Both ligands documented significant age-related decreases in dopamine D2 receptors that occurred relatively early in life (40 years of age).",

keywords = "Aging, Neurodegeneration, Positron emission tomography, Striatum",

author = "Volkow, {Nora D.} and Wang, {Gene Jack} and Fowler, {Joanna S.} and Jean Logan and Gatley, {Samuel J.} and MacGregor, {Robert R.} and Schlyer, {David J.} and Robert Hitzemann and Wolf, {Alfred P.}",

note = "Funding Information: This research was supported in part by the U.S. Department of Energy under Contract DE-AC02-76CHOOO16a nd National Institute on Drug Abuse Grant No. SROl-DA06891. We thank Robert Carciello and Babe Barrett for cyclotron operations; Donald Warner for PET operations; Colleen Shea and Payton King for radiotracer preparation and analysis; Katy Pascani, Naome Pappas and Gail Burr for subject evaluation; Noelwah Netusil for patient care; and Carol Redvanly for scheduling and organization.",

year = "1996",

month = may,

day = "31",

doi = "10.1016/0925-4927(96)02809-0",

language = "English (US)",

volume = "67",

pages = "11--16",

journal = "Psychiatry Research - Neuroimaging",

issn = "0925-4927",

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T1 - Measuring age-related changes in dopamine D2 receptors with 11C-raclopride and 18F-N-methylspiroperidol

AU - Volkow, Nora D.

AU - Wang, Gene Jack

AU - Fowler, Joanna S.

AU - Logan, Jean

AU - Gatley, Samuel J.

AU - MacGregor, Robert R.

AU - Schlyer, David J.

AU - Hitzemann, Robert

AU - Wolf, Alfred P.

N1 - Funding Information: This research was supported in part by the U.S. Department of Energy under Contract DE-AC02-76CHOOO16a nd National Institute on Drug Abuse Grant No. SROl-DA06891. We thank Robert Carciello and Babe Barrett for cyclotron operations; Donald Warner for PET operations; Colleen Shea and Payton King for radiotracer preparation and analysis; Katy Pascani, Naome Pappas and Gail Burr for subject evaluation; Noelwah Netusil for patient care; and Carol Redvanly for scheduling and organization.

PY - 1996/5/31

Y1 - 1996/5/31

N2 - This study investigates the rate of age-related dopamine D2 receptor loss as determined by positron emission tomography (PET) and 11C-raclopride and compares it with D2 loss previously estimated with 18F-N-methylspiroperidol (NMS). Dopamine D2 receptors were measured with 11C-raclopride in 24 healthy volunteers (24-73 years of age) using the ratio of the distribution volume in striatum to that in cerebellum (Bmax/Kd + 1). The results were compared with those obtained in 20 healthy male volunteers (20-49 years of age) in whom D2 receptors were measured with NMS using the ratio index (slope of the striatum-to-cerebellum ratio as a function of time). Findings of correlational analysis between age and dopamine D2 receptor availability were significant for both ligands. Estimates of dopamine D2 receptor loss per decade corresponded to 7.9% for the 11C-raclopride study and 7.8% for the NMS study. Both ligands documented significant age-related decreases in dopamine D2 receptors that occurred relatively early in life (40 years of age).

AB - This study investigates the rate of age-related dopamine D2 receptor loss as determined by positron emission tomography (PET) and 11C-raclopride and compares it with D2 loss previously estimated with 18F-N-methylspiroperidol (NMS). Dopamine D2 receptors were measured with 11C-raclopride in 24 healthy volunteers (24-73 years of age) using the ratio of the distribution volume in striatum to that in cerebellum (Bmax/Kd + 1). The results were compared with those obtained in 20 healthy male volunteers (20-49 years of age) in whom D2 receptors were measured with NMS using the ratio index (slope of the striatum-to-cerebellum ratio as a function of time). Findings of correlational analysis between age and dopamine D2 receptor availability were significant for both ligands. Estimates of dopamine D2 receptor loss per decade corresponded to 7.9% for the 11C-raclopride study and 7.8% for the NMS study. Both ligands documented significant age-related decreases in dopamine D2 receptors that occurred relatively early in life (40 years of age).

KW - Aging

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