Measurement science in the circulatory system

Casey M. Jones, Sandra M. Baker-Groberg, Flor A. Cianchetti, Jeremy J. Glynn, Laura D. Healy, Wai Yan Lam, Jonathan W. Nelson, Diana C. Parrish, Kevin G. Phillips, Devon E. Scott-Drechsel, Ian J. Tagge, Jaime E. Zelaya, Monica T. Hinds, Owen J.T. McCarty

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


The dynamics of the cellular and molecular constituents of the circulatory system are regulated by the biophysical properties of the heart, vasculature and blood cells and proteins. In this review, we discuss measurement techniques that have been developed to characterize the physical and mechanical parameters of the circulatory system across length scales ranging from the tissue scale (cm) to the molecular scale (nm) and time scales of years to milliseconds. We compare the utility of measurement techniques as a function of spatial resolution and penetration depth from both a diagnostic and research perspective. Together, this review provides an overview of the utility of measurement science techniques to study the spatial systems of the circulatory system in health and disease.

Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
JournalCellular and Molecular Bioengineering
Issue number1
StatePublished - Mar 2014


  • Blood
  • Microscopy
  • Physical parameters

ASJC Scopus subject areas

  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)


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