Measurement of total blood flow in the normal human retina using Doppler Fourier-domain optical coherence tomography

Y. Wang, A. Lu, J. Gil-Flamer, Ou Tan, J. A. Izatt, David Huang

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Aim: To measure total retinal blood flow in normal human eyes using Doppler Fourier-domain optical coherence tomography (FD-OCT). Methods: 10 normal people aged 35 to 69 years were measured for the right eye using Doppler FD-OCT. Double circular scans around the optic nerve heads were used. Four pairs of circular scans that transected all retinal branch vessels were completed in 2 s. Total retinal blood flow was obtained by summing the flows in the branch veins. Measurements from the eight scans were averaged. Veins with diameters 33 mm were taken into account. Results: Total retinal blood flow could be measured in eight of 10 subjects: mean (SD) = 45.6 (3.8) ml/min (range 40.8 to 52.9 ml/min). The coefficient of variation for repeated measurements was 10.5%. Measured vein diameters ranged from 33.3 to 155.4 mm. The averaged flow speed was 19.3 (2.9) mm/s, which did not correlate with vessel diameter. There was no significant difference between flows in the superior and inferior retinal hemispheres. Conclusions: Double circular scanning using Doppler FD- OCT is a rapid and reproducible method to measure total retinal blood flow. These flow values are within the range previously established by laser Doppler flowmetry.

Original languageEnglish (US)
Pages (from-to)634-637
Number of pages4
JournalBritish Journal of Ophthalmology
Volume93
Issue number5
DOIs
StatePublished - May 2009
Externally publishedYes

Fingerprint

Optical Coherence Tomography
Retina
Veins
Retinal Vessels
Laser-Doppler Flowmetry
Optic Disk

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience
  • Medicine(all)

Cite this

Measurement of total blood flow in the normal human retina using Doppler Fourier-domain optical coherence tomography. / Wang, Y.; Lu, A.; Gil-Flamer, J.; Tan, Ou; Izatt, J. A.; Huang, David.

In: British Journal of Ophthalmology, Vol. 93, No. 5, 05.2009, p. 634-637.

Research output: Contribution to journalArticle

@article{7587cae23e7941d98f6521a4a4d48adc,
title = "Measurement of total blood flow in the normal human retina using Doppler Fourier-domain optical coherence tomography",
abstract = "Aim: To measure total retinal blood flow in normal human eyes using Doppler Fourier-domain optical coherence tomography (FD-OCT). Methods: 10 normal people aged 35 to 69 years were measured for the right eye using Doppler FD-OCT. Double circular scans around the optic nerve heads were used. Four pairs of circular scans that transected all retinal branch vessels were completed in 2 s. Total retinal blood flow was obtained by summing the flows in the branch veins. Measurements from the eight scans were averaged. Veins with diameters 33 mm were taken into account. Results: Total retinal blood flow could be measured in eight of 10 subjects: mean (SD) = 45.6 (3.8) ml/min (range 40.8 to 52.9 ml/min). The coefficient of variation for repeated measurements was 10.5{\%}. Measured vein diameters ranged from 33.3 to 155.4 mm. The averaged flow speed was 19.3 (2.9) mm/s, which did not correlate with vessel diameter. There was no significant difference between flows in the superior and inferior retinal hemispheres. Conclusions: Double circular scanning using Doppler FD- OCT is a rapid and reproducible method to measure total retinal blood flow. These flow values are within the range previously established by laser Doppler flowmetry.",
author = "Y. Wang and A. Lu and J. Gil-Flamer and Ou Tan and Izatt, {J. A.} and David Huang",
year = "2009",
month = "5",
doi = "10.1136/bjo.2008.150276",
language = "English (US)",
volume = "93",
pages = "634--637",
journal = "British Journal of Ophthalmology",
issn = "0007-1161",
publisher = "BMJ Publishing Group",
number = "5",

}

TY - JOUR

T1 - Measurement of total blood flow in the normal human retina using Doppler Fourier-domain optical coherence tomography

AU - Wang, Y.

AU - Lu, A.

AU - Gil-Flamer, J.

AU - Tan, Ou

AU - Izatt, J. A.

AU - Huang, David

PY - 2009/5

Y1 - 2009/5

N2 - Aim: To measure total retinal blood flow in normal human eyes using Doppler Fourier-domain optical coherence tomography (FD-OCT). Methods: 10 normal people aged 35 to 69 years were measured for the right eye using Doppler FD-OCT. Double circular scans around the optic nerve heads were used. Four pairs of circular scans that transected all retinal branch vessels were completed in 2 s. Total retinal blood flow was obtained by summing the flows in the branch veins. Measurements from the eight scans were averaged. Veins with diameters 33 mm were taken into account. Results: Total retinal blood flow could be measured in eight of 10 subjects: mean (SD) = 45.6 (3.8) ml/min (range 40.8 to 52.9 ml/min). The coefficient of variation for repeated measurements was 10.5%. Measured vein diameters ranged from 33.3 to 155.4 mm. The averaged flow speed was 19.3 (2.9) mm/s, which did not correlate with vessel diameter. There was no significant difference between flows in the superior and inferior retinal hemispheres. Conclusions: Double circular scanning using Doppler FD- OCT is a rapid and reproducible method to measure total retinal blood flow. These flow values are within the range previously established by laser Doppler flowmetry.

AB - Aim: To measure total retinal blood flow in normal human eyes using Doppler Fourier-domain optical coherence tomography (FD-OCT). Methods: 10 normal people aged 35 to 69 years were measured for the right eye using Doppler FD-OCT. Double circular scans around the optic nerve heads were used. Four pairs of circular scans that transected all retinal branch vessels were completed in 2 s. Total retinal blood flow was obtained by summing the flows in the branch veins. Measurements from the eight scans were averaged. Veins with diameters 33 mm were taken into account. Results: Total retinal blood flow could be measured in eight of 10 subjects: mean (SD) = 45.6 (3.8) ml/min (range 40.8 to 52.9 ml/min). The coefficient of variation for repeated measurements was 10.5%. Measured vein diameters ranged from 33.3 to 155.4 mm. The averaged flow speed was 19.3 (2.9) mm/s, which did not correlate with vessel diameter. There was no significant difference between flows in the superior and inferior retinal hemispheres. Conclusions: Double circular scanning using Doppler FD- OCT is a rapid and reproducible method to measure total retinal blood flow. These flow values are within the range previously established by laser Doppler flowmetry.

UR - http://www.scopus.com/inward/record.url?scp=66149144821&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=66149144821&partnerID=8YFLogxK

U2 - 10.1136/bjo.2008.150276

DO - 10.1136/bjo.2008.150276

M3 - Article

VL - 93

SP - 634

EP - 637

JO - British Journal of Ophthalmology

JF - British Journal of Ophthalmology

SN - 0007-1161

IS - 5

ER -