Measurement of strain and strain rate in embryonic chick heart in vivo using spectral domain optical coherence tomography

Peng Li, Xin Yin, Liang Shi, Aiping Liu, Sandra Rugonyi, Ruikang K. Wang

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The ability to measure in vivo strain and strain rate in embryonic chick heart is one of the key requirements for understanding the mechanisms of cardiac development. Due to its high temporal and spatial resolution as well as its fast imaging capability, optical coherence tomography (OCT) has the potential to reveal the complex myocardial activity in the living chick heart. We describe a method to evaluate the in vivo strain and strain rate of the myocardium through analyzing the periodic variation of the myocardial wall thickness calculated from real-time serial OCT images. The results demonstrate that OCT can be a useful tool to describe the biomechanical characteristics of the embryonic heart.

Original languageEnglish (US)
Article number5766020
Pages (from-to)2333-2338
Number of pages6
JournalIEEE Transactions on Biomedical Engineering
Volume58
Issue number8
DOIs
StatePublished - Aug 2011

Keywords

  • Cardiac development
  • embryonic chick heart
  • medical and biological imaging
  • myocardial strain
  • optical coherence tomography

ASJC Scopus subject areas

  • Biomedical Engineering

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