Measurement of strain and strain rate in embryonic chick heart in vivo using spectral domain optical coherence tomography

Peng Li; Xin Yin; Liang Shi; Aiping Liu; Sandra Rugonyi; Ruikang K. Wang

doi:10.1109/TBME.2011.2153851

Measurement of strain and strain rate in embryonic chick heart in vivo using spectral domain optical coherence tomography

Peng Li, Xin Yin, Liang Shi, Aiping Liu, Sandra Rugonyi, Ruikang K. Wang

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

The ability to measure in vivo strain and strain rate in embryonic chick heart is one of the key requirements for understanding the mechanisms of cardiac development. Due to its high temporal and spatial resolution as well as its fast imaging capability, optical coherence tomography (OCT) has the potential to reveal the complex myocardial activity in the living chick heart. We describe a method to evaluate the in vivo strain and strain rate of the myocardium through analyzing the periodic variation of the myocardial wall thickness calculated from real-time serial OCT images. The results demonstrate that OCT can be a useful tool to describe the biomechanical characteristics of the embryonic heart.

Original language	English (US)
Article number	5766020
Pages (from-to)	2333-2338
Number of pages	6
Journal	IEEE Transactions on Biomedical Engineering
Volume	58
Issue number	8
DOIs	https://doi.org/10.1109/TBME.2011.2153851
State	Published - Aug 2011

Keywords

Cardiac development
embryonic chick heart
medical and biological imaging
myocardial strain
optical coherence tomography

ASJC Scopus subject areas

Biomedical Engineering

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10.1109/TBME.2011.2153851

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title = "Measurement of strain and strain rate in embryonic chick heart in vivo using spectral domain optical coherence tomography",

abstract = "The ability to measure in vivo strain and strain rate in embryonic chick heart is one of the key requirements for understanding the mechanisms of cardiac development. Due to its high temporal and spatial resolution as well as its fast imaging capability, optical coherence tomography (OCT) has the potential to reveal the complex myocardial activity in the living chick heart. We describe a method to evaluate the in vivo strain and strain rate of the myocardium through analyzing the periodic variation of the myocardial wall thickness calculated from real-time serial OCT images. The results demonstrate that OCT can be a useful tool to describe the biomechanical characteristics of the embryonic heart.",

keywords = "Cardiac development, embryonic chick heart, medical and biological imaging, myocardial strain, optical coherence tomography",

author = "Peng Li and Xin Yin and Liang Shi and Aiping Liu and Sandra Rugonyi and Wang, {Ruikang K.}",

note = "Funding Information: Manuscript received December 23, 2010; revised March 31, 2011; accepted May 4, 2011. Date of publication May 12, 2011; date of current version July 20, 2011. This work was supported in part by the National Heart, Blood, and Lung Institute under NIH Grant R01HL094570. Asterisk indicates corresponding author.",

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AU - Shi, Liang

AU - Liu, Aiping

AU - Rugonyi, Sandra

AU - Wang, Ruikang K.

N1 - Funding Information: Manuscript received December 23, 2010; revised March 31, 2011; accepted May 4, 2011. Date of publication May 12, 2011; date of current version July 20, 2011. This work was supported in part by the National Heart, Blood, and Lung Institute under NIH Grant R01HL094570. Asterisk indicates corresponding author.

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N2 - The ability to measure in vivo strain and strain rate in embryonic chick heart is one of the key requirements for understanding the mechanisms of cardiac development. Due to its high temporal and spatial resolution as well as its fast imaging capability, optical coherence tomography (OCT) has the potential to reveal the complex myocardial activity in the living chick heart. We describe a method to evaluate the in vivo strain and strain rate of the myocardium through analyzing the periodic variation of the myocardial wall thickness calculated from real-time serial OCT images. The results demonstrate that OCT can be a useful tool to describe the biomechanical characteristics of the embryonic heart.

AB - The ability to measure in vivo strain and strain rate in embryonic chick heart is one of the key requirements for understanding the mechanisms of cardiac development. Due to its high temporal and spatial resolution as well as its fast imaging capability, optical coherence tomography (OCT) has the potential to reveal the complex myocardial activity in the living chick heart. We describe a method to evaluate the in vivo strain and strain rate of the myocardium through analyzing the periodic variation of the myocardial wall thickness calculated from real-time serial OCT images. The results demonstrate that OCT can be a useful tool to describe the biomechanical characteristics of the embryonic heart.

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Measurement of strain and strain rate in embryonic chick heart in vivo using spectral domain optical coherence tomography

Abstract

Keywords

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