Abstract
A method which utilized the absorption of 125I as a measure of intestinal mucosal blood flow was developed. In the pentobarbital anesthetized dog a segment of mid-jejunum was isolated from adjacent vasculature and perfused with 125I solution. Superior mesenteric artery flow, blood flow to the isolated segment of intestine and 125I absorption were measured. Changes in 125I absorption were found to correlate closely with changes in blood flow (r = 0.95). Using an autoradiographic technique 125I absorption was found to be localized to the intestinal mucosa.
Original language | English (US) |
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Pages (from-to) | 65-75 |
Number of pages | 11 |
Journal | Journal of Pharmacological Methods |
Volume | 6 |
Issue number | 1 |
DOIs | |
State | Published - Aug 1981 |
Externally published | Yes |
Keywords
- Blood flow
- Gut blood flow
- Intestinal mucosa
- Mesenteric circulation
ASJC Scopus subject areas
- Pharmacology