Measurement of central corneal thickness by high-resolution Scheimpflug imaging, Fourier-domain optical coherence tomography and ultrasound pachymetry

Shihao Chen, Jinhai Huang, Daizong Wen, Wuhe Chen, David Huang, Qinmei Wang

Research output: Contribution to journalArticle

72 Scopus citations


Purpose: To compare the repeatability and reproducibility of central corneal thickness (CCT) measurements by high-resolution (HR) rotating Scheimpflug imaging and Fourier-domain optical coherence tomography (FD-OCT). CCT measurements were compared to those determined by ultrasound pachymetry (UP). Methods: In 35 healthy eyes, intra-observer repeatability for HR Scheimpflug (Pentacam) and FD-OCT (RTVue) systems was determined in consecutive images taken by an observer in the shortest time possible. Imaging was repeated again by a second observer to evaluate inter-observer reproducibility. The CCT measurements were compared among Scheimpflug, FD-OCT and UP images. Results: Mean coefficients of repeatability were 0.48% for Scheimpflug and 0.26% for FD-OCT. For Scheimpflug, the coefficient of inter-operator reproducibility was 0.87%. For FD-OCT, the coefficient of inter-operator reproducibility was 0.45%. The CCT measurements by Scheimpflug, OCT and UP images were (mean ± standard deviation) 521.7 ± 27.6 μm, 510.8 ± 28.6 μm and 516.5 ± 27.6 μm, respectively. The differences between instruments were statistically significant. The 95% limits of agreement in CCT were -0.7 to 22.5 μm for Pentacam-OCT, -13.4 to 24.0 μm for Pentacam-UP and -26.7 to 15.4 μm for OCT-UP. There was a high degree of correlation between CCT measured by all 3 methods. Conclusion: Noncontact measurements of CCT with HR Scheimpflug and FD-OCT systems yielded excellent repeatability and reproducibility and can be used interchangeably. Although both devices were comparable with UP; in clinical practice, the measurements acquired by optical modalities are not directly interchangeable with UP measurements.

Original languageEnglish (US)
Pages (from-to)449-455
Number of pages7
JournalActa Ophthalmologica
Issue number5
Publication statusPublished - Aug 2012
Externally publishedYes



  • agreement
  • cornea thickness
  • optical coherence tomography
  • repeatability
  • reproducibility
  • rotating Scheimpflug imaging

ASJC Scopus subject areas

  • Ophthalmology

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