Measurement of basilar membrane, reticular lamina, and tectorial membrane vibrations in the intact mouse cochlea

Tianying Ren, Wenxuan He

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

A scanning low-coherence heterodyne interferometer (SLHI) was developed for measuring the microstructural vibration inside the cochlear partition of the intact living cochlea of mice. The sensitivity, frequency response, and dynamic range of the SLHI are comparable with those of a sensitive laser interferometer but the SLHI has a higher spatial resolution along the optical axis. The magnitude and phase of sound-induced vibrations were measured as a function of the focal position along the optical axis. Our data show that the SLHI has sufficient sensitivity, dynamic range, and temporal and spatial resolution to measure sub-nanometer vibrations of the basilar membrane, reticular lamina, and tectorial membrane in the intact living mouse cochlea. High spatial and temporal resolution, compact heterodyne design, and scanning capability make this interferometer an ideal tool to study molecular mechanisms of hearing in normal and genetically-modified mice.

Original languageEnglish (US)
Title of host publicationAIP Conference Proceedings
Pages423-428
Number of pages6
Volume1403
DOIs
StatePublished - 2011
Event11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics - Williamstown, MA, United States
Duration: Jul 16 2011Jul 22 2011

Other

Other11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics
CountryUnited States
CityWilliamstown, MA
Period7/16/117/22/11

Fingerprint

cochlea
mice
interferometers
membranes
vibration
scanning
spatial resolution
temporal resolution
dynamic range
sensitivity
high resolution
hearing
frequency response
partitions
acoustics
lasers

Keywords

  • basilar membrane
  • cochlea
  • low-coherence interferometer
  • reticular lamina
  • tectorial membrane

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Measurement of basilar membrane, reticular lamina, and tectorial membrane vibrations in the intact mouse cochlea. / Ren, Tianying; He, Wenxuan.

AIP Conference Proceedings. Vol. 1403 2011. p. 423-428.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ren, T & He, W 2011, Measurement of basilar membrane, reticular lamina, and tectorial membrane vibrations in the intact mouse cochlea. in AIP Conference Proceedings. vol. 1403, pp. 423-428, 11th International Mechanics of Hearing Workshop - What Fire is in Mine Ears: Progress in Auditory Biomechanics, Williamstown, MA, United States, 7/16/11. https://doi.org/10.1063/1.3658124
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