Abstract
Unilateral experimental endolymphatic hydrops was created by endolymphatic sac and duct obstruction in guinea pigs. Studies of action potential (AP) threshold were then performed and compared with histologic findings. Action potential thresholds were significantly increased in the hydrops ears. The close relationship between AP changes and hydrops was sufficient to allow the detection of hydrops by AP threshold measurements alone. The AP threshold changes were positively related to the degree of hydrops and postoperative interval in a manner consistent with hearing changes seen in Meniere's disease. Based upon the foregoing, experimental endolymphatic hydrops appears to be a valid and usable model for the study of the cochlear aspects of Meniere's disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 191-194 |
| Number of pages | 4 |
| Journal | Annals of Otology, Rhinology and Laryngology |
| Volume | 94 |
| Issue number | 2 I |
| State | Published - 1985 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Otorhinolaryngology
Cite this
Measurement of action potential thresholds in experimental endolymphatic hydrops. / Morizono, T.; Cohen, James; Sikora, M. A.
In: Annals of Otology, Rhinology and Laryngology, Vol. 94, No. 2 I, 1985, p. 191-194.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Measurement of action potential thresholds in experimental endolymphatic hydrops
AU - Morizono, T.
AU - Cohen, James
AU - Sikora, M. A.
PY - 1985
Y1 - 1985
N2 - Unilateral experimental endolymphatic hydrops was created by endolymphatic sac and duct obstruction in guinea pigs. Studies of action potential (AP) threshold were then performed and compared with histologic findings. Action potential thresholds were significantly increased in the hydrops ears. The close relationship between AP changes and hydrops was sufficient to allow the detection of hydrops by AP threshold measurements alone. The AP threshold changes were positively related to the degree of hydrops and postoperative interval in a manner consistent with hearing changes seen in Meniere's disease. Based upon the foregoing, experimental endolymphatic hydrops appears to be a valid and usable model for the study of the cochlear aspects of Meniere's disease.
AB - Unilateral experimental endolymphatic hydrops was created by endolymphatic sac and duct obstruction in guinea pigs. Studies of action potential (AP) threshold were then performed and compared with histologic findings. Action potential thresholds were significantly increased in the hydrops ears. The close relationship between AP changes and hydrops was sufficient to allow the detection of hydrops by AP threshold measurements alone. The AP threshold changes were positively related to the degree of hydrops and postoperative interval in a manner consistent with hearing changes seen in Meniere's disease. Based upon the foregoing, experimental endolymphatic hydrops appears to be a valid and usable model for the study of the cochlear aspects of Meniere's disease.
UR - http://www.scopus.com/inward/record.url?scp=0021990050&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021990050&partnerID=8YFLogxK
M3 - Article
C2 - 3994240
AN - SCOPUS:0021990050
VL - 94
SP - 191
EP - 194
JO - Annals of Otology, Rhinology and Laryngology
JF - Annals of Otology, Rhinology and Laryngology
SN - 0003-4894
IS - 2 I
ER -