Measurement of action potential thresholds in experimental endolymphatic hydrops

T. Morizono, James Cohen, M. A. Sikora

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Unilateral experimental endolymphatic hydrops was created by endolymphatic sac and duct obstruction in guinea pigs. Studies of action potential (AP) threshold were then performed and compared with histologic findings. Action potential thresholds were significantly increased in the hydrops ears. The close relationship between AP changes and hydrops was sufficient to allow the detection of hydrops by AP threshold measurements alone. The AP threshold changes were positively related to the degree of hydrops and postoperative interval in a manner consistent with hearing changes seen in Meniere's disease. Based upon the foregoing, experimental endolymphatic hydrops appears to be a valid and usable model for the study of the cochlear aspects of Meniere's disease.

Original languageEnglish (US)
Pages (from-to)191-194
Number of pages4
JournalAnnals of Otology, Rhinology and Laryngology
Volume94
Issue number2 I
StatePublished - 1985
Externally publishedYes

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Endolymphatic Hydrops
Action Potentials
Edema
Meniere Disease
Endolymphatic Duct
Endolymphatic Sac
Cochlea
Hearing
Ear
Guinea Pigs

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Measurement of action potential thresholds in experimental endolymphatic hydrops. / Morizono, T.; Cohen, James; Sikora, M. A.

In: Annals of Otology, Rhinology and Laryngology, Vol. 94, No. 2 I, 1985, p. 191-194.

Research output: Contribution to journalArticle

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