Measured gene-by-environment interaction in relation to attention-deficit/hyperactivity disorder

Joel Nigg, Molly Nikolas, S. Alexandra Burt

Research output: Contribution to journalReview article

125 Scopus citations

Abstract

Objective: To summarize and evaluate the state of knowledge regarding the role of measured gene-by-environment interactions in relation to attention-deficit/hyperactivity disorder. Method: A selective review of methodologic issues was followed by a systematic search for relevant articles on measured gene-by-environment interactions; the search yielded 16 studies, which are discussed in qualitative fashion. Results: Relatively consistent evidence points to the interaction of genotype with psychosocial factors in the development of attention-deficit/hyperactivity disorder. The next step is to identify the mechanisms on the environment side and the gene combinations on the genetic side accounting for this effect. In contrast, evidence for gene-by-environment interactions involving pre- and perinatal risk factors is generally negative or unreplicated. The aggregate effect size for psychosocial interaction with genotype is more than double that for the interaction of pre- and perinatal risks with genotype. Only a small fraction of candidate environments and gene markers has been studied, and multivariate methods to integrate multiple gene or environment markers have yet to be implemented. Conclusions: Gene-by-environment interaction appears likely to prove fruitful in understanding the etiology of attention-deficit/hyperactivity disorder. Findings to date already suggest new avenues of investigation particularly involving psychosocial mechanisms and their interplay with genotype. Further pursuit of theoretically promising leads is recommended.

Original languageEnglish (US)
Pages (from-to)863-873
Number of pages11
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume49
Issue number9
DOIs
StatePublished - Sep 1 2010

Keywords

  • attention-deficit hyperactivity disorder
  • environment
  • gene
  • gene-by-environment interaction

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychiatry and Mental health

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