Abstract
With the growing class of CFTR modulator therapy available to more patients and with increasing pregnancies in individuals with CF, there is a growing need to understand the effects of these agents during pregnancy. There are few reports of their continued use in the literature, although it is likely that this is not an uncommon occurrence. We report the uncomplicated and successful pregnancy of a woman treated with lumacaftor/ivacaftor, as well as the clinical course of the infant during the first 9 months of life. We also report drug levels in plasma from the mother, cord blood, breast milk, and infant to estimate fetal and infant drug exposure.
Original language | English (US) |
---|---|
Pages (from-to) | 779-782 |
Number of pages | 4 |
Journal | Journal of Cystic Fibrosis |
Volume | 17 |
Issue number | 6 |
DOIs | |
State | Published - Nov 2018 |
Externally published | Yes |
Keywords
- CFTR modulators
- Ivacaftor
- Lumacaftor
- Pregnancy
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Pulmonary and Respiratory Medicine