Maturational changes in cell surface antigen expression in the mouse retina and optic pathway

Zhi Ping Mi, Weili Weng, Mark Hankin, Vinodh Narayanan, Carl F. Lagenaur

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The distribution of the cell surface molecules M6 and L1 was studied using the immunohistochemistry and in situ hybridization in the developing and adult mouse retina and optic nerve. L1 is a cell adhesion molecule while M6 is a cell surface molecule homologous to the myelin protein proteolipid protein (PLP/DM20). Although both molecules were expressed in retina and optic nerves of embryonic and neonatal mice, our studies show that their patterns of postnatal expression are quite different. While L1 continues to be expressed in optic axons throughout adulthood, expression of M6 on optic axons declines after birth and instead becomes strongly expressed on Muller glial endfeet and in the inner plexiform layer. The modulation of these molecules after birth could provide clues to changing cell-cell interactions occurring in the proximal portion of the optic pathway.

Original languageEnglish (US)
Pages (from-to)145-154
Number of pages10
JournalDevelopmental Brain Research
Volume106
Issue number1-2
DOIs
StatePublished - Mar 12 1998
Externally publishedYes

Fingerprint

Surface Antigens
Optic Nerve
Axons
Retina
Myelin Proteolipid Protein
Parturition
Cell Adhesion Molecules
Cell Communication
Neuroglia
In Situ Hybridization
Immunohistochemistry
Proteins

Keywords

  • L1
  • M6
  • Optic fibers
  • Retinal ganglion cell

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

Cite this

Maturational changes in cell surface antigen expression in the mouse retina and optic pathway. / Mi, Zhi Ping; Weng, Weili; Hankin, Mark; Narayanan, Vinodh; Lagenaur, Carl F.

In: Developmental Brain Research, Vol. 106, No. 1-2, 12.03.1998, p. 145-154.

Research output: Contribution to journalArticle

Mi, Zhi Ping ; Weng, Weili ; Hankin, Mark ; Narayanan, Vinodh ; Lagenaur, Carl F. / Maturational changes in cell surface antigen expression in the mouse retina and optic pathway. In: Developmental Brain Research. 1998 ; Vol. 106, No. 1-2. pp. 145-154.
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