Maturation of the angiotensin II cardiovascular response in the embryonic White Leghorn chicken (Gallus gallus)

Dane A. Crossley; Sonnet S. Jonker; James W. Hicks; Kent L. Thornburg

doi:10.1007/s00360-010-0473-y

Maturation of the angiotensin II cardiovascular response in the embryonic White Leghorn chicken (Gallus gallus)

Dane A. Crossley, Sonnet S. Jonker, James W. Hicks, Kent L. Thornburg

Knight Cardiovascular Institute

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Angiotensin II (Ang II) is an important regulator of cardiovascular function in adult vertebrates. Although its role in regulating the adult system has been extensively investigated, the cardiovascular response to Ang II in embryonic vertebrates is relatively unknown. We investigated the potential of Ang II as a regulator of cardiovascular function in embryonic chickens, which lack central nervous system control of cardiovascular function throughout the majority of incubation. The cardiovascular response to Ang II in embryonic chickens was investigated over the final 50% of their development. Ang II produced a dose-dependent increase in arterial pressure on each day of development studied, and the response increased in intensity as development progressed. The Ang II type-1 receptor nonspecific competitive peptide antagonist [Sar¹ ile⁸] Ang II blocked the cardiovascular response to subsequent injections of Ang II on day 21 only. The embryonic pressure response to Ang II (hypertension only) differed from that of adult chickens, in which initial hypotension is followed by hypertension. The constant level of gene expression for the Ang II receptor, in conjunction with an increasing pressure response to the peptide, suggests that two Ang II receptor subtypes are present during chicken development. Collectively, the data indicate that Ang II plays an important role in the cardiovascular development of chickens; however, its role in maintaining basal function requires further study.

Original language	English (US)
Pages (from-to)	1057-1065
Number of pages	9
Journal	Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology
Volume	180
Issue number	7
DOIs	https://doi.org/10.1007/s00360-010-0473-y
State	Published - 2010

Keywords

Development
Pharmacology
Physiology
Vertebrates

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Biochemistry
Physiology
Animal Science and Zoology
Endocrinology

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10.1007/s00360-010-0473-y

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Maturation of the angiotensin II cardiovascular response in the embryonic White Leghorn chicken (Gallus gallus). / Crossley, Dane A.; Jonker, Sonnet S.; Hicks, James W. et al.
In: Journal of Comparative Physiology B: Biochemical, Systemic, and Environmental Physiology, Vol. 180, No. 7, 2010, p. 1057-1065.

Research output: Contribution to journal › Article › peer-review

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abstract = "Angiotensin II (Ang II) is an important regulator of cardiovascular function in adult vertebrates. Although its role in regulating the adult system has been extensively investigated, the cardiovascular response to Ang II in embryonic vertebrates is relatively unknown. We investigated the potential of Ang II as a regulator of cardiovascular function in embryonic chickens, which lack central nervous system control of cardiovascular function throughout the majority of incubation. The cardiovascular response to Ang II in embryonic chickens was investigated over the final 50% of their development. Ang II produced a dose-dependent increase in arterial pressure on each day of development studied, and the response increased in intensity as development progressed. The Ang II type-1 receptor nonspecific competitive peptide antagonist [Sar1 ile8] Ang II blocked the cardiovascular response to subsequent injections of Ang II on day 21 only. The embryonic pressure response to Ang II (hypertension only) differed from that of adult chickens, in which initial hypotension is followed by hypertension. The constant level of gene expression for the Ang II receptor, in conjunction with an increasing pressure response to the peptide, suggests that two Ang II receptor subtypes are present during chicken development. Collectively, the data indicate that Ang II plays an important role in the cardiovascular development of chickens; however, its role in maintaining basal function requires further study.",

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N1 - Funding Information: Acknowledgments We are greatly indebted to Robert Webber, Krista Wherly, Samantha Louey, and George Giraud for their assistance in completing this project. We would also like to acknowledge Janna Mabey, Renee Mabey, Kevin Tate, Justin Swart, and Diane Darland for their editing suggestions on the manuscript. This research was supported by American Heart Association Postdoctoral fellowship #0120044Y, National Science Foundation Career Award IBN-IOS0845741 to D.A.C. II, funding from NSF grant IBN-IOB04445680 to J.W.H., and NIH grant IBN-2PO1HD34430 to K.T.

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AB - Angiotensin II (Ang II) is an important regulator of cardiovascular function in adult vertebrates. Although its role in regulating the adult system has been extensively investigated, the cardiovascular response to Ang II in embryonic vertebrates is relatively unknown. We investigated the potential of Ang II as a regulator of cardiovascular function in embryonic chickens, which lack central nervous system control of cardiovascular function throughout the majority of incubation. The cardiovascular response to Ang II in embryonic chickens was investigated over the final 50% of their development. Ang II produced a dose-dependent increase in arterial pressure on each day of development studied, and the response increased in intensity as development progressed. The Ang II type-1 receptor nonspecific competitive peptide antagonist [Sar1 ile8] Ang II blocked the cardiovascular response to subsequent injections of Ang II on day 21 only. The embryonic pressure response to Ang II (hypertension only) differed from that of adult chickens, in which initial hypotension is followed by hypertension. The constant level of gene expression for the Ang II receptor, in conjunction with an increasing pressure response to the peptide, suggests that two Ang II receptor subtypes are present during chicken development. Collectively, the data indicate that Ang II plays an important role in the cardiovascular development of chickens; however, its role in maintaining basal function requires further study.

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Maturation of the angiotensin II cardiovascular response in the embryonic White Leghorn chicken (Gallus gallus)

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