Matrix metalloproteinases in human choroidal neovascular membranes excised following verteporfin photodynamic therapy

Olcay Tatar, Annemarie Adam, Kei Shinoda, Tillmann Eckert, Gábor B. Scharioth, Michael Klein, Efdal Yoeruek, Karl Ulrich Bartz-Schmidt, Salvatore Grisanti

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Aim: To evaluate expression of proangiogenic matrix metalloproteinases (MMP) 2 and 9 at distinct intervals after verteporfin photodynamic therapy (PDT) in human choroidal neovascular membranes (CNV) secondary to age-related macular degeneration (AMD). Methods: Retrospective review of an interventional case series of 49 patients who underwent removal of CNV. Twenty-six patients were treated with PDT 3 to 383 days prior to surgery. Twenty-three CNV without previous treatment were used as controls. CNV were stained for CD34, cytokeratin 18, endostatin, MMP-2 and MMP-9 by immunohistochemistry. Results: CNV without previous therapy disclosed MMP-2, MMP-9 in RPE-Bruch's membrane, vessels and stroma in different intensities. Three days after PDT, MMP-9 expression was significantly weaker in stroma (p = 0.0019). Endostatin was significantly reduced in vessels (p

Original languageEnglish (US)
Pages (from-to)1183-1189
Number of pages7
JournalBritish Journal of Ophthalmology
Volume91
Issue number9
DOIs
StatePublished - Sep 2007
Externally publishedYes

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Photochemotherapy
Matrix Metalloproteinases
Matrix Metalloproteinase 9
Matrix Metalloproteinase 2
Membranes
Endostatins
Bruch Membrane
Keratin-18
Macular Degeneration
Immunohistochemistry
verteporfin
Therapeutics

ASJC Scopus subject areas

  • Ophthalmology

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Matrix metalloproteinases in human choroidal neovascular membranes excised following verteporfin photodynamic therapy. / Tatar, Olcay; Adam, Annemarie; Shinoda, Kei; Eckert, Tillmann; Scharioth, Gábor B.; Klein, Michael; Yoeruek, Efdal; Bartz-Schmidt, Karl Ulrich; Grisanti, Salvatore.

In: British Journal of Ophthalmology, Vol. 91, No. 9, 09.2007, p. 1183-1189.

Research output: Contribution to journalArticle

Tatar, O, Adam, A, Shinoda, K, Eckert, T, Scharioth, GB, Klein, M, Yoeruek, E, Bartz-Schmidt, KU & Grisanti, S 2007, 'Matrix metalloproteinases in human choroidal neovascular membranes excised following verteporfin photodynamic therapy', British Journal of Ophthalmology, vol. 91, no. 9, pp. 1183-1189. https://doi.org/10.1136/bjo.2007.114769
Tatar, Olcay ; Adam, Annemarie ; Shinoda, Kei ; Eckert, Tillmann ; Scharioth, Gábor B. ; Klein, Michael ; Yoeruek, Efdal ; Bartz-Schmidt, Karl Ulrich ; Grisanti, Salvatore. / Matrix metalloproteinases in human choroidal neovascular membranes excised following verteporfin photodynamic therapy. In: British Journal of Ophthalmology. 2007 ; Vol. 91, No. 9. pp. 1183-1189.
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AU - Klein, Michael

AU - Yoeruek, Efdal

AU - Bartz-Schmidt, Karl Ulrich

AU - Grisanti, Salvatore

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