Matrix metalloproteinases and the development of cancer

Lisa M. Coussens, Zena Werb

Research output: Contribution to journalReview articlepeer-review

493 Scopus citations

Abstract

Proteolytic remodeling of the extracellular matrix is an important aspect of the creation and progression of cancer. Matrix metalloproteinases are important at several points during multistage neoplastic progression in tumor cells and responding blood vessels, inflammatory cells and stroma.

Original languageEnglish (US)
Pages (from-to)895-904
Number of pages10
JournalChemistry and Biology
Volume3
Issue number11
DOIs
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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