Matrix metalloproteinases and the development of cancer

Lisa M. Coussens; Zena Werb

doi:10.1016/S1074-5521(96)90178-7

Matrix metalloproteinases and the development of cancer

Lisa M. Coussens, Zena Werb

Research output: Contribution to journal › Review article › peer-review

515 Scopus citations

Abstract

Proteolytic remodeling of the extracellular matrix is an important aspect of the creation and progression of cancer. Matrix metalloproteinases are important at several points during multistage neoplastic progression in tumor cells and responding blood vessels, inflammatory cells and stroma.

Original language	English (US)
Pages (from-to)	895-904
Number of pages	10
Journal	Chemistry and Biology
Volume	3
Issue number	11
DOIs	https://doi.org/10.1016/S1074-5521(96)90178-7
State	Published - 1996
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmacology
Drug Discovery
Clinical Biochemistry

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10.1016/S1074-5521(96)90178-7

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@article{e559431c543443769491edfb67d3fa62,

title = "Matrix metalloproteinases and the development of cancer",

abstract = "Proteolytic remodeling of the extracellular matrix is an important aspect of the creation and progression of cancer. Matrix metalloproteinases are important at several points during multistage neoplastic progression in tumor cells and responding blood vessels, inflammatory cells and stroma.",

author = "Coussens, {Lisa M.} and Zena Werb",

note = "Funding Information: We acknowledge all the scientists who made contributions to the areas of research reviewed here that we could not cite due to space constraints. This work was supported in part by funds from the National Institutes of Health (CA 09043) to LMC, and (CA 57621 and CA52071 to ZW.",

year = "1996",

doi = "10.1016/S1074-5521(96)90178-7",

language = "English (US)",

volume = "3",

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journal = "Chemistry and Biology",

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TY - JOUR

T1 - Matrix metalloproteinases and the development of cancer

AU - Coussens, Lisa M.

AU - Werb, Zena

N1 - Funding Information: We acknowledge all the scientists who made contributions to the areas of research reviewed here that we could not cite due to space constraints. This work was supported in part by funds from the National Institutes of Health (CA 09043) to LMC, and (CA 57621 and CA52071 to ZW.

PY - 1996

Y1 - 1996

N2 - Proteolytic remodeling of the extracellular matrix is an important aspect of the creation and progression of cancer. Matrix metalloproteinases are important at several points during multistage neoplastic progression in tumor cells and responding blood vessels, inflammatory cells and stroma.

AB - Proteolytic remodeling of the extracellular matrix is an important aspect of the creation and progression of cancer. Matrix metalloproteinases are important at several points during multistage neoplastic progression in tumor cells and responding blood vessels, inflammatory cells and stroma.

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U2 - 10.1016/S1074-5521(96)90178-7

DO - 10.1016/S1074-5521(96)90178-7

M3 - Review article

C2 - 8939708

AN - SCOPUS:0030293598

SN - 1074-5521

VL - 3

SP - 895

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JO - Chemistry and Biology

JF - Chemistry and Biology

IS - 11

ER -

Matrix metalloproteinases and the development of cancer

Abstract

ASJC Scopus subject areas

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