TY - JOUR
T1 - Maternal serum biomarkers for risk assessment in gestational diabetes. A potential universal screening test to predict GDM status
AU - Nagalla, Srinivasa R.
AU - Snyder, Caryn K.
AU - Michaels, John E.
AU - Laughlin, Mary J.
AU - Roberts, Charles T.
AU - Balaji, Madhuri
AU - Balaji, V.
AU - Seshiah, V.
AU - Rao, Paturi V.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - The prevalence of gestational diabetes mellitus (GDM) is increasing because of the worldwide obesity/diabetes epidemic. The complications of untreated GDM affect both the mother and baby and include complications during pregnancy as well as increased risk of subsequent type-2 diabetes in mothers and offspring. Standard tests for hyperglycemia in diabetes, such as fasting glucose and hemoglobin (HbA1c), are currently not recommended for GDM screening. Instead, an oral glucose tolerance test is specified, which is invasive, time-consuming, and not easily accessible to many at-risk populations. In this study, we describe a multi-analyte maternal serum profile test that incorporates novel glycoprotein biomarkers and previously described GDM-associated markers. In screening for GDM by multi-analyte panel, the detection rate was 87% at a false-positive rate of 1%.
AB - The prevalence of gestational diabetes mellitus (GDM) is increasing because of the worldwide obesity/diabetes epidemic. The complications of untreated GDM affect both the mother and baby and include complications during pregnancy as well as increased risk of subsequent type-2 diabetes in mothers and offspring. Standard tests for hyperglycemia in diabetes, such as fasting glucose and hemoglobin (HbA1c), are currently not recommended for GDM screening. Instead, an oral glucose tolerance test is specified, which is invasive, time-consuming, and not easily accessible to many at-risk populations. In this study, we describe a multi-analyte maternal serum profile test that incorporates novel glycoprotein biomarkers and previously described GDM-associated markers. In screening for GDM by multi-analyte panel, the detection rate was 87% at a false-positive rate of 1%.
KW - Gestational diabetes
KW - glycosylated fibronectin
KW - maternal serum biomarker
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U2 - 10.4103/2230-8210.140226
DO - 10.4103/2230-8210.140226
M3 - Article
AN - SCOPUS:84981164530
SN - 2230-8210
VL - 19
SP - 155
EP - 159
JO - Indian Journal of Endocrinology and Metabolism
JF - Indian Journal of Endocrinology and Metabolism
IS - 1
ER -