Maternal high-fat diet reversal improves placental hemodynamics in a nonhuman primate model of diet-induced obesity

Jennifer A. Salati, Victoria Roberts, Matthias Schabel, Jamie Lo, Christopher (Chris) Kroenke, Katherine S. Lewandowski, Jonathan Lindner, Kevin Grove, Antonio Frias

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: In a Japanese macaque model of diet-induced obesity, we have previously demonstrated that consumption of a high-fat, “Western-style” diet (WSD) is associated with placental dysfunction and adverse pregnancy outcomes, independent of an obese maternal phenotype. Specifically, we have reported decreased uterine placental blood flow and increased inflammation with maternal WSD consumption. We also previously investigated the use of a promising therapeutic intervention that mitigated the adverse placental effects of a WSD but had unexpected detrimental effects on fetal pancreatic development. Thus, the objective of the current study was to determine whether simple preconception diet reversal (REV) would improve placental function. Methods: Female Japanese macaques were divided into three groups: REV animals (n = 5) were switched from a chronic WSD (36% fat) to a low fat, CON diet (14% fat) prior to conception and throughout pregnancy. The CON (n = 6) and WSD (n = 6) cohorts were maintained on their respective diets throughout pregnancy. Maternal body weight and composition were regularly assessed and advanced noninvasive imaging was performed at midgestation (gestational day 90, G90, or 0.5 of gestation, where full term is G175), and G129, 1 day prior to C-section delivery at G130 (0.75 of gestation). Imaging studies comprised Doppler ultrasound (US), contrast-enhanced US, and dynamic contrast-enhanced magnetic resonance imaging to assess uteroplacental hemodynamics and maternal-side placental perfusion. Results: Dietary intervention resulted in significant maternal weight loss prior to pregnancy, and improved lean to fat mass ratio. By advanced imaging we demonstrated that a chronic WSD led to decreased blood flow velocity in the intervillous space, delayed blood flow transfer through the maternal spiral arteries, and reduced total placental blood flow compared to CON fed animals. Dietary reversal ameliorated these concerning derangements, restoring these hemodynamic parameters to CON levels. Conclusions: Preconception dietary modification has beneficial effects on the maternal metabolic phenotype, and results in improved placental hemodynamics.

Original languageEnglish (US)
Pages (from-to)1-11
Number of pages11
JournalInternational Journal of Obesity
DOIs
StateAccepted/In press - Jul 13 2018

Fingerprint

High Fat Diet
Primates
Obesity
Hemodynamics
Mothers
Diet
Pregnancy
Fats
Macaca
Diet Therapy
Phenotype
Doppler Ultrasonography
Fat-Restricted Diet
Blood Flow Velocity
Pregnancy Outcome
Fetal Development
Body Composition
Weight Loss
Arteries
Perfusion

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Maternal high-fat diet reversal improves placental hemodynamics in a nonhuman primate model of diet-induced obesity. / Salati, Jennifer A.; Roberts, Victoria; Schabel, Matthias; Lo, Jamie; Kroenke, Christopher (Chris); Lewandowski, Katherine S.; Lindner, Jonathan; Grove, Kevin; Frias, Antonio.

In: International Journal of Obesity, 13.07.2018, p. 1-11.

Research output: Contribution to journalArticle

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abstract = "Background: In a Japanese macaque model of diet-induced obesity, we have previously demonstrated that consumption of a high-fat, “Western-style” diet (WSD) is associated with placental dysfunction and adverse pregnancy outcomes, independent of an obese maternal phenotype. Specifically, we have reported decreased uterine placental blood flow and increased inflammation with maternal WSD consumption. We also previously investigated the use of a promising therapeutic intervention that mitigated the adverse placental effects of a WSD but had unexpected detrimental effects on fetal pancreatic development. Thus, the objective of the current study was to determine whether simple preconception diet reversal (REV) would improve placental function. Methods: Female Japanese macaques were divided into three groups: REV animals (n = 5) were switched from a chronic WSD (36{\%} fat) to a low fat, CON diet (14{\%} fat) prior to conception and throughout pregnancy. The CON (n = 6) and WSD (n = 6) cohorts were maintained on their respective diets throughout pregnancy. Maternal body weight and composition were regularly assessed and advanced noninvasive imaging was performed at midgestation (gestational day 90, G90, or 0.5 of gestation, where full term is G175), and G129, 1 day prior to C-section delivery at G130 (0.75 of gestation). Imaging studies comprised Doppler ultrasound (US), contrast-enhanced US, and dynamic contrast-enhanced magnetic resonance imaging to assess uteroplacental hemodynamics and maternal-side placental perfusion. Results: Dietary intervention resulted in significant maternal weight loss prior to pregnancy, and improved lean to fat mass ratio. By advanced imaging we demonstrated that a chronic WSD led to decreased blood flow velocity in the intervillous space, delayed blood flow transfer through the maternal spiral arteries, and reduced total placental blood flow compared to CON fed animals. Dietary reversal ameliorated these concerning derangements, restoring these hemodynamic parameters to CON levels. Conclusions: Preconception dietary modification has beneficial effects on the maternal metabolic phenotype, and results in improved placental hemodynamics.",
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AU - Lewandowski, Katherine S.

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