Maternal high-fat diet programming of the neuroendocrine system and behavior

Elinor Sullivan, Kellie M. Riper, Rachel Lockard, Jeanette C. Valleau

    Research output: Contribution to journalArticle

    45 Citations (Scopus)

    Abstract

    This article is part of a Special Issue "SBN 2014".Maternal obesity, metabolic state, and diet during gestation have profound effects on offspring development. The prevalence of neurodevelopmental and mental health disorders has risen rapidly in the last several decades in parallel with the rise in obesity rates. Evidence from epidemiological studies indicates that maternal obesity and metabolic complications increase the risk of offspring developing behavioral disorders such as attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (ASD), and schizophrenia. Animal models show that a maternal diet high in fat similarly disrupts behavioral programming of offspring, with animals showing social impairments, increased anxiety and depressive behaviors, reduced cognitive development, and hyperactivity. Maternal obesity, metabolic conditions, and high fat diet consumption increase maternal leptin, insulin, glucose, triglycerides, and inflammatory cytokines. This leads to increased risk of placental dysfunction, and altered fetal neuroendocrine development. Changes in brain development that likely contribute to the increased risk of behavioral and mental health disorders include increased inflammation in the brain, as well as alterations in the serotonergic system, dopaminergic system and hypothalamic-pituitary-adrenal (HPA) axis.

    Original languageEnglish (US)
    Pages (from-to)153-161
    Number of pages9
    JournalHormones and Behavior
    Volume76
    DOIs
    StatePublished - Nov 1 2015

    Fingerprint

    Neurosecretory Systems
    High Fat Diet
    Mothers
    Obesity
    Mental Disorders
    Mental Health
    Pituitary-Adrenal System
    Encephalitis
    Attention Deficit Disorder with Hyperactivity
    Fetal Development
    Leptin
    Epidemiologic Studies
    Schizophrenia
    Triglycerides
    Anxiety
    Animal Models
    Insulin
    Cytokines
    Diet
    Glucose

    Keywords

    • ADHD
    • Anxiety
    • Autism
    • High-fat diet
    • Maternal obesity
    • Pregnancy
    • Programming
    • Schizophrenia

    ASJC Scopus subject areas

    • Endocrinology
    • Behavioral Neuroscience
    • Endocrine and Autonomic Systems

    Cite this

    Maternal high-fat diet programming of the neuroendocrine system and behavior. / Sullivan, Elinor; Riper, Kellie M.; Lockard, Rachel; Valleau, Jeanette C.

    In: Hormones and Behavior, Vol. 76, 01.11.2015, p. 153-161.

    Research output: Contribution to journalArticle

    Sullivan, Elinor ; Riper, Kellie M. ; Lockard, Rachel ; Valleau, Jeanette C. / Maternal high-fat diet programming of the neuroendocrine system and behavior. In: Hormones and Behavior. 2015 ; Vol. 76. pp. 153-161.
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