Maternal high-fat diet disturbs uteroplacental hemodynamics and increases the frequency of stillbirth in a nonhuman primate model of excess nutrition

Antonio Frias, Terry Morgan, Anne E. Evans, Juha Rasanen, Karen Oh, Kent Thornburg, Kevin Grove

Research output: Contribution to journalArticle

153 Citations (Scopus)

Abstract

Prepregnancy maternal obesity confers an increased risk of stillbirth, but the mechanisms are unknown. Maternal obesity is associated with placental inflammation. We considered that maternal diet may predispose to the increased risk of placental inflammation and stillbirth. We hypothesized that a chronic high-fat diet (HFD) is associated with abnormal uteroplacental circulation and placental inflammation. Here we used a nonhuman primate model to determine the effect of chronic HFD on the uterine and placental hemodynamics, placental histology, and inflammation in a prospective, observational study of 24 Japanese macaques. Overall, there was a statistically significant (38-56%) reduction in uterine volume blood flow from HFD animals, whether they were lean or obese. Consumption of a HFD, independent of obesity, increased placental inflammatory cytokines and the expression of Toll-like receptor 4. We show that HFD consumption by obese mothers with hyperinsulinemia also reduced volume blood flowonthe fetal side of the placenta and significantly increased the frequency of both placental infarctions and stillbirth. These results suggest that a HFD, independent of obesity, decreases uterine volume blood flow. Maternal obesity and insulin resistance further exacerbates the placental dysfunction and results in an increased frequency of stillbirth.

Original languageEnglish (US)
Pages (from-to)2456-2464
Number of pages9
JournalEndocrinology
Volume152
Issue number6
DOIs
StatePublished - Jun 2011

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Stillbirth
High Fat Diet
Primates
Hemodynamics
Mothers
Obesity
Blood Volume
Inflammation
Placental Circulation
Toll-Like Receptor 4
Hyperinsulinism
Macaca
Fetal Blood
Infarction
Placenta
Observational Studies
Insulin Resistance
Histology
Prospective Studies
Cytokines

ASJC Scopus subject areas

  • Endocrinology

Cite this

Maternal high-fat diet disturbs uteroplacental hemodynamics and increases the frequency of stillbirth in a nonhuman primate model of excess nutrition. / Frias, Antonio; Morgan, Terry; Evans, Anne E.; Rasanen, Juha; Oh, Karen; Thornburg, Kent; Grove, Kevin.

In: Endocrinology, Vol. 152, No. 6, 06.2011, p. 2456-2464.

Research output: Contribution to journalArticle

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