Maternal Cortisol Concentrations During Pregnancy and Sex-Specific Associations With Neonatal Amygdala Connectivity and Emerging Internalizing Behaviors

Alice M. Graham, Jerod M. Rasmussen, Sonja Entringer, Elizabeth Ben Ward, Marc D. Rudolph, John H. Gilmore, Martin Styner, Pathik D. Wadhwa, Damien Fair, Claudia Buss

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Maternal cortisol during pregnancy has the potential to influence rapidly developing fetal brain systems that are commonly altered in neurodevelopmental and psychiatric disorders. Research examining maternal cortisol concentrations across pregnancy and offspring neurodevelopment proximal to birth is needed to advance understanding in this area and lead to insight into the etiology of these disorders. Methods: Participants were 70 adult women recruited during early pregnancy and their infants born after 34 weeks gestation. Maternal cortisol concentrations were assessed serially over 4 days in early, mid, and late gestation. Resting state functional connectivity magnetic resonance imaging of the neonatal amygdala was examined. Mothers reported on children's internalizing behavior problems at 24 months of age. Results: Maternal cortisol concentrations during pregnancy were significantly associated with neonatal amygdala connectivity in a sex-specific manner. Elevated maternal cortisol was associated with stronger amygdala connectivity to brain regions involved in sensory processing and integration, as well as the default mode network in girls, and with weaker connectivity to these brain regions in boys. Elevated maternal cortisol was associated with higher internalizing symptoms in girls only, and this association was mediated by stronger neonatal amygdala connectivity. Conclusions: Normative variation in maternal cortisol during pregnancy is associated with the coordinated functioning of the amygdala soon after birth in a sex-specific manner. The identified pathway from maternal cortisol to higher internalizing symptoms in girls via alterations in neonatal amygdala connectivity may be relevant for the etiology of sex differences in internalizing psychiatric disorders, which are more prevalent in women.

Original languageEnglish (US)
Pages (from-to)172-181
Number of pages10
JournalBiological Psychiatry
Volume85
Issue number2
DOIs
StatePublished - Jan 15 2019

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Amygdala
Hydrocortisone
Mothers
Pregnancy
Psychiatry
Brain
Parturition
Child Behavior
Sex Characteristics
Magnetic Resonance Imaging
Research

Keywords

  • Amygdala
  • Cortisol
  • Infancy
  • Internalizing
  • Pregnancy
  • Resting state functional connectivity MRI

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Maternal Cortisol Concentrations During Pregnancy and Sex-Specific Associations With Neonatal Amygdala Connectivity and Emerging Internalizing Behaviors. / Graham, Alice M.; Rasmussen, Jerod M.; Entringer, Sonja; Ben Ward, Elizabeth; Rudolph, Marc D.; Gilmore, John H.; Styner, Martin; Wadhwa, Pathik D.; Fair, Damien; Buss, Claudia.

In: Biological Psychiatry, Vol. 85, No. 2, 15.01.2019, p. 172-181.

Research output: Contribution to journalArticle

Graham, AM, Rasmussen, JM, Entringer, S, Ben Ward, E, Rudolph, MD, Gilmore, JH, Styner, M, Wadhwa, PD, Fair, D & Buss, C 2019, 'Maternal Cortisol Concentrations During Pregnancy and Sex-Specific Associations With Neonatal Amygdala Connectivity and Emerging Internalizing Behaviors', Biological Psychiatry, vol. 85, no. 2, pp. 172-181. https://doi.org/10.1016/j.biopsych.2018.06.023
Graham, Alice M. ; Rasmussen, Jerod M. ; Entringer, Sonja ; Ben Ward, Elizabeth ; Rudolph, Marc D. ; Gilmore, John H. ; Styner, Martin ; Wadhwa, Pathik D. ; Fair, Damien ; Buss, Claudia. / Maternal Cortisol Concentrations During Pregnancy and Sex-Specific Associations With Neonatal Amygdala Connectivity and Emerging Internalizing Behaviors. In: Biological Psychiatry. 2019 ; Vol. 85, No. 2. pp. 172-181.
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