Maternal antibiotic use during pregnancy and childhood obesity at age 5 years

On behalf of the PCORnet Antibiotics and Childhood Growth Study Group

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Objective: The benefits of antibiotic treatment during pregnancy are immediate, but there may be long-term risks to the developing child. Prior studies show an association between early life antibiotics and obesity, but few have examined this risk during pregnancy. Subjects: To evaluate the association of maternal antibiotic exposure during pregnancy on childhood BMI-z at 5 years, we conducted a retrospective cohort analysis. Using electronic health record data from seven health systems in PCORnet, a national distributed clinical research network, we included children with same-day height and weight measures who could be linked to mothers with vital measurements during pregnancy. The primary independent variable was maternal outpatient antibiotic prescriptions during pregnancy (any versus none). We examined dose response (number of antibiotic episodes), spectrum and class of antibiotics, and antibiotic episodes by trimester. The primary outcome was child age- and sex-specific BMI-z at age 5 years. Results: The final sample was 53,320 mother–child pairs. During pregnancy, 29.9% of mothers received antibiotics. In adjusted models, maternal outpatient antibiotic prescriptions during pregnancy were not associated with child BMI-z at age 5 years (β = 0.00, 95% CI −0.03, 0.02). When evaluating timing during pregnancy, dose-response, spectrum and class of antibiotics, there were no associations of maternal antibiotics with child BMI-z at age 5 years. Conclusion: In this large observational cohort, provision of antibiotics during pregnancy was not associated with childhood BMI-z at 5 years.

Original languageEnglish (US)
Pages (from-to)1202-1209
Number of pages8
JournalInternational Journal of Obesity
Volume43
Issue number6
DOIs
StatePublished - Jun 1 2019

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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    On behalf of the PCORnet Antibiotics and Childhood Growth Study Group (2019). Maternal antibiotic use during pregnancy and childhood obesity at age 5 years. International Journal of Obesity, 43(6), 1202-1209. https://doi.org/10.1038/s41366-018-0316-6