Maternal Adaptations to Pregnancy

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A woman's body responds to pregnancy by making a series of profound structural and physiological changes. She burns an additional ∼400. kcal/day at rest and increases her oxygen consumption by ∼33% compared to her nonpregnant state. The average weight gain of a woman is ∼12. kg over the course of pregnancy. Maternal blood volume increases by 30-50% during pregnancy, and the heart chambers enlarge allowing a larger stroke volume. Together with the increased heart rate and decreased vascular resistance to flow, cardiac output often increases by ∼50%. Women who are pregnant hyperventilate and increasingly drive their arterial carbon dioxide tensions down, resulting in a mild compensated respiratory alkalosis. Women retain water during pregnancy, and associated renal changes are dramatic. Effective renal plasma flow and glomerular filtration rate increase over the course of gestation as renal vascular resistance is decreased. The molecular mechanisms underlying these changes have been little studied.

Original languageEnglish (US)
Title of host publicationKnobil and Neill's Physiology of Reproduction: Two-Volume Set
PublisherElsevier Inc.
Pages1927-1955
Number of pages29
Volume2
ISBN (Print)9780123977694, 9780123971753
DOIs
StatePublished - Dec 23 2014

Fingerprint

Mothers
Pregnancy
Vascular Resistance
Respiratory Alkalosis
Effective Renal Plasma Flow
Kidney
Blood Volume
Glomerular Filtration Rate
Carbon Dioxide
Oxygen Consumption
Cardiac Output
Stroke Volume
Weight Gain
Pregnant Women
Heart Rate
Water

Keywords

  • Adjustments to pregnancy
  • Cardiovascular adaptations
  • Fetal development
  • Physiology of pregnancy
  • Pregnancy
  • Renal adaptations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Thornburg, K., Bagby, S., & Giraud, G. (2014). Maternal Adaptations to Pregnancy. In Knobil and Neill's Physiology of Reproduction: Two-Volume Set (Vol. 2, pp. 1927-1955). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-397175-3.00043-0

Maternal Adaptations to Pregnancy. / Thornburg, Kent; Bagby, Susan; Giraud, George.

Knobil and Neill's Physiology of Reproduction: Two-Volume Set. Vol. 2 Elsevier Inc., 2014. p. 1927-1955.

Research output: Chapter in Book/Report/Conference proceedingChapter

Thornburg, K, Bagby, S & Giraud, G 2014, Maternal Adaptations to Pregnancy. in Knobil and Neill's Physiology of Reproduction: Two-Volume Set. vol. 2, Elsevier Inc., pp. 1927-1955. https://doi.org/10.1016/B978-0-12-397175-3.00043-0
Thornburg K, Bagby S, Giraud G. Maternal Adaptations to Pregnancy. In Knobil and Neill's Physiology of Reproduction: Two-Volume Set. Vol. 2. Elsevier Inc. 2014. p. 1927-1955 https://doi.org/10.1016/B978-0-12-397175-3.00043-0
Thornburg, Kent ; Bagby, Susan ; Giraud, George. / Maternal Adaptations to Pregnancy. Knobil and Neill's Physiology of Reproduction: Two-Volume Set. Vol. 2 Elsevier Inc., 2014. pp. 1927-1955
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