TY - JOUR
T1 - Mast cell disease associated with acute myeloid leukemia
T2 - Detection of a new c-kit mutation Asp816His
AU - Pullarkat, Vinod A.
AU - Pullarkat, Sheeja T.
AU - Calverley, David C.
AU - Brynes, Russell K.
PY - 2000
Y1 - 2000
N2 - Mast cell disease (MCD), a proliferation of mast cells (MC), is occasionally associated with hematologic malignancies. Neoplastic MC have activating c-kit mutations, c-kit is a receptor tyrosine kinase required for the development, proliferation, and survival of MC. Interaction of c-kit with its ligand stem cell factor induces dimerization, receptor phosphorylation, and signal transduction. The most common c-kit mutation detected in neoplastic MCD is Asp816Val, which results in ligand-independent autophosphorylation of the receptor leading to MC proliferation. We describe the rare occurrence of MCD associated with acute myeloid leukemia, report a novel c-kit mutation Asp816 His, and discuss the pathogenesis of MCD associated with hematologic malignancies. (C) 2000 Wiley-Liss, Inc.
AB - Mast cell disease (MCD), a proliferation of mast cells (MC), is occasionally associated with hematologic malignancies. Neoplastic MC have activating c-kit mutations, c-kit is a receptor tyrosine kinase required for the development, proliferation, and survival of MC. Interaction of c-kit with its ligand stem cell factor induces dimerization, receptor phosphorylation, and signal transduction. The most common c-kit mutation detected in neoplastic MCD is Asp816Val, which results in ligand-independent autophosphorylation of the receptor leading to MC proliferation. We describe the rare occurrence of MCD associated with acute myeloid leukemia, report a novel c-kit mutation Asp816 His, and discuss the pathogenesis of MCD associated with hematologic malignancies. (C) 2000 Wiley-Liss, Inc.
KW - Acute myeloid leukemia
KW - Mast cell disease
KW - Mutation
KW - c-kit
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U2 - 10.1002/1096-8652(200012)65:4<307::AID-AJH10>3.0.CO;2-F
DO - 10.1002/1096-8652(200012)65:4<307::AID-AJH10>3.0.CO;2-F
M3 - Article
C2 - 11074560
AN - SCOPUS:0033749308
SN - 0361-8609
VL - 65
SP - 307
EP - 309
JO - American Journal of Hematology
JF - American Journal of Hematology
IS - 4
ER -