Massive verapamil ingestion: A report of two cases and a review of the literature

B (Zane) Horowitz, Kenneth J. Rhee

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

This report describes two patients who were victims of massive verapamil ingestion and then reviews the available literature. Because verapamil blocks the slow calcium channels of the heart and blood vessels, the use of calcium as a treatment would be logical. In the two cases reported here, calcium was only transiently effective in maintaining cardiac output and blood pressure. Several other agents were then used and most were ineffective. This is similar to experience reported in the literature that suggests that no single agent is capable of reversing verapamil's negative inotropic, dromotropic, chronotropic, and vascular smooth muscle effects.

Original languageEnglish (US)
Pages (from-to)624-631
Number of pages8
JournalAmerican Journal of Emergency Medicine
Volume7
Issue number6
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Verapamil
Eating
Calcium
Calcium Channels
Vascular Smooth Muscle
Cardiac Output
Blood Vessels
Blood Pressure
Therapeutics

Keywords

  • calcium channel blockers
  • Verapamil

ASJC Scopus subject areas

  • Emergency Medicine

Cite this

Massive verapamil ingestion : A report of two cases and a review of the literature. / Horowitz, B (Zane); Rhee, Kenneth J.

In: American Journal of Emergency Medicine, Vol. 7, No. 6, 1989, p. 624-631.

Research output: Contribution to journalArticle

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