Massive verapamil ingestion: A report of two cases and a review of the literature

B (Zane) Horowitz, Kenneth J. Rhee

Research output: Contribution to journalArticle

60 Scopus citations


This report describes two patients who were victims of massive verapamil ingestion and then reviews the available literature. Because verapamil blocks the slow calcium channels of the heart and blood vessels, the use of calcium as a treatment would be logical. In the two cases reported here, calcium was only transiently effective in maintaining cardiac output and blood pressure. Several other agents were then used and most were ineffective. This is similar to experience reported in the literature that suggests that no single agent is capable of reversing verapamil's negative inotropic, dromotropic, chronotropic, and vascular smooth muscle effects.

Original languageEnglish (US)
Pages (from-to)624-631
Number of pages8
JournalAmerican Journal of Emergency Medicine
Issue number6
Publication statusPublished - 1989
Externally publishedYes



  • calcium channel blockers
  • Verapamil

ASJC Scopus subject areas

  • Emergency Medicine

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