Massive strychnine intoxication

Serial blood levels in a fatal case

John M. Heiser, Mohamud Ramzan Daya, A. Roy Magnussen, Robert Norton, Daniel A. Spyker, David W. Allen, Wendell Krasselt

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

A fatal case of strychnine intoxication is reported. The patient expired despite early aggressive management and prevention of metabolic complications. Serial blood levels are reported. In contrast to a previous report describing first order elimination kinetics, our data suggest that strychnine follows Michaelis-Menton elimination kinetics. The case illustrates the rapid, dramatic course of severe strychnine ingestions. A review of the toxicokinetics, mechanism of action and treatment of strychnine intoxication follows.

Original languageEnglish (US)
Pages (from-to)269-283
Number of pages15
JournalClinical Toxicology
Volume30
Issue number2
DOIs
StatePublished - 1992

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Strychnine
Blood
Kinetics
Eating
Therapeutics

Keywords

  • Pharmacokinetics
  • Poisoning, human
  • Review
  • Strychnine

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Heiser, J. M., Daya, M. R., Magnussen, A. R., Norton, R., Spyker, D. A., Allen, D. W., & Krasselt, W. (1992). Massive strychnine intoxication: Serial blood levels in a fatal case. Clinical Toxicology, 30(2), 269-283. https://doi.org/10.3109/15563659209038638

Massive strychnine intoxication : Serial blood levels in a fatal case. / Heiser, John M.; Daya, Mohamud Ramzan; Magnussen, A. Roy; Norton, Robert; Spyker, Daniel A.; Allen, David W.; Krasselt, Wendell.

In: Clinical Toxicology, Vol. 30, No. 2, 1992, p. 269-283.

Research output: Contribution to journalArticle

Heiser, JM, Daya, MR, Magnussen, AR, Norton, R, Spyker, DA, Allen, DW & Krasselt, W 1992, 'Massive strychnine intoxication: Serial blood levels in a fatal case', Clinical Toxicology, vol. 30, no. 2, pp. 269-283. https://doi.org/10.3109/15563659209038638
Heiser, John M. ; Daya, Mohamud Ramzan ; Magnussen, A. Roy ; Norton, Robert ; Spyker, Daniel A. ; Allen, David W. ; Krasselt, Wendell. / Massive strychnine intoxication : Serial blood levels in a fatal case. In: Clinical Toxicology. 1992 ; Vol. 30, No. 2. pp. 269-283.
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