Massive strychnine intoxication: Serial blood levels in a fatal case

John M. Heiser, Mohamud R. Daya, A. Roy Magnussen, Robert L. Norton, Daniel A. Spyker, David W. Allen, Wendell Krasselt

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

A fatal case of strychnine intoxication is reported. The patient expired despite early aggressive management and prevention of metabolic complications. Serial blood levels are reported. In contrast to a previous report describing first order elimination kinetics, our data suggest that strychnine follows Michaelis-Menton elimination kinetics. The case illustrates the rapid, dramatic course of severe strychnine ingestions. A review of the toxicokinetics, mechanism of action and treatment of strychnine intoxication follows.

Original languageEnglish (US)
Pages (from-to)269-283
Number of pages15
JournalClinical Toxicology
Volume30
Issue number2
DOIs
StatePublished - Jan 1 1992

Keywords

  • Pharmacokinetics
  • Poisoning, human
  • Review
  • Strychnine

ASJC Scopus subject areas

  • Toxicology

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    Heiser, J. M., Daya, M. R., Magnussen, A. R., Norton, R. L., Spyker, D. A., Allen, D. W., & Krasselt, W. (1992). Massive strychnine intoxication: Serial blood levels in a fatal case. Clinical Toxicology, 30(2), 269-283. https://doi.org/10.3109/15563659209038638