Massive strychnine intoxication: Serial blood levels in a fatal case

John M. Heiser; Mohamud R. Daya; A. Roy Magnussen; Robert L. Norton; Daniel A. Spyker; David W. Allen; Wendell Krasselt

doi:10.3109/15563659209038638

Massive strychnine intoxication: Serial blood levels in a fatal case

John M. Heiser, Mohamud R. Daya, A. Roy Magnussen, Robert L. Norton, Daniel A. Spyker, David W. Allen, Wendell Krasselt

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39 Scopus citations

Abstract

A fatal case of strychnine intoxication is reported. The patient expired despite early aggressive management and prevention of metabolic complications. Serial blood levels are reported. In contrast to a previous report describing first order elimination kinetics, our data suggest that strychnine follows Michaelis-Menton elimination kinetics. The case illustrates the rapid, dramatic course of severe strychnine ingestions. A review of the toxicokinetics, mechanism of action and treatment of strychnine intoxication follows.

Original language	English (US)
Pages (from-to)	269-283
Number of pages	15
Journal	Clinical Toxicology
Volume	30
Issue number	2
DOIs	https://doi.org/10.3109/15563659209038638
State	Published - 1992

Keywords

Pharmacokinetics
Poisoning, human
Review
Strychnine

ASJC Scopus subject areas

Toxicology

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10.3109/15563659209038638

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title = "Massive strychnine intoxication: Serial blood levels in a fatal case",

abstract = "A fatal case of strychnine intoxication is reported. The patient expired despite early aggressive management and prevention of metabolic complications. Serial blood levels are reported. In contrast to a previous report describing first order elimination kinetics, our data suggest that strychnine follows Michaelis-Menton elimination kinetics. The case illustrates the rapid, dramatic course of severe strychnine ingestions. A review of the toxicokinetics, mechanism of action and treatment of strychnine intoxication follows.",

keywords = "Pharmacokinetics, Poisoning, human, Review, Strychnine",

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year = "1992",

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language = "English (US)",

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AU - Heiser, John M.

AU - Daya, Mohamud R.

AU - Magnussen, A. Roy

AU - Norton, Robert L.

AU - Spyker, Daniel A.

AU - Allen, David W.

AU - Krasselt, Wendell

PY - 1992

Y1 - 1992

N2 - A fatal case of strychnine intoxication is reported. The patient expired despite early aggressive management and prevention of metabolic complications. Serial blood levels are reported. In contrast to a previous report describing first order elimination kinetics, our data suggest that strychnine follows Michaelis-Menton elimination kinetics. The case illustrates the rapid, dramatic course of severe strychnine ingestions. A review of the toxicokinetics, mechanism of action and treatment of strychnine intoxication follows.

AB - A fatal case of strychnine intoxication is reported. The patient expired despite early aggressive management and prevention of metabolic complications. Serial blood levels are reported. In contrast to a previous report describing first order elimination kinetics, our data suggest that strychnine follows Michaelis-Menton elimination kinetics. The case illustrates the rapid, dramatic course of severe strychnine ingestions. A review of the toxicokinetics, mechanism of action and treatment of strychnine intoxication follows.

KW - Pharmacokinetics

KW - Poisoning, human

KW - Review

KW - Strychnine

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Massive strychnine intoxication: Serial blood levels in a fatal case

Abstract

Keywords

ASJC Scopus subject areas

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