Maribavir antagonizes the antiviral action of ganciclovir on human cytomegalovirus

Sunwen Chou, Gail I. Marousek

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The cytomegalovirus (CMV) UL97 kinase inhibitor maribavir antagonized the anti-CMV effect of ganciclovir, increasing the ganciclovir 50% inhibitory concentration against a sensitive strain by up to 13-fold. Antiviral activities of foscarnet and cidofovir were unaffected by maribavir.

Original languageEnglish (US)
Pages (from-to)3470-3472
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume50
Issue number10
DOIs
StatePublished - Oct 2006

Fingerprint

Ganciclovir
Cytomegalovirus
Antiviral Agents
Foscarnet
Inhibitory Concentration 50
Phosphotransferases
maribavir
cidofovir

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Maribavir antagonizes the antiviral action of ganciclovir on human cytomegalovirus. / Chou, Sunwen; Marousek, Gail I.

In: Antimicrobial Agents and Chemotherapy, Vol. 50, No. 10, 10.2006, p. 3470-3472.

Research output: Contribution to journalArticle

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