TY - GEN
T1 - Mapping tissue optical attenuation to identify cancer using optical coherence tomography
AU - McLaughlin, Robert A.
AU - Scolaro, Loretta
AU - Robbins, Peter
AU - Saunders, Christobel
AU - Jacques, Steven L.
AU - Sampson, David D.
PY - 2009
Y1 - 2009
N2 - The lymphatic system is a common route for the spread of cancer and the identification of lymph node metastases is a key task during cancer surgery. This paper demonstrates the use of optical coherence tomography to construct parametric images of lymph nodes. It describes a method to automatically estimate the optical attenuation coefficient of tissue. By mapping the optical attenuation coefficient at each location in the scan, it is possible to construct a parametric image indicating variations in tissue type. The algorithm is applied to ex vivo samples of human axillary lymph nodes and validated against a histological gold standard. Results are shown illustrating the variation in optical properties between cancerous and healthy tissue.
AB - The lymphatic system is a common route for the spread of cancer and the identification of lymph node metastases is a key task during cancer surgery. This paper demonstrates the use of optical coherence tomography to construct parametric images of lymph nodes. It describes a method to automatically estimate the optical attenuation coefficient of tissue. By mapping the optical attenuation coefficient at each location in the scan, it is possible to construct a parametric image indicating variations in tissue type. The algorithm is applied to ex vivo samples of human axillary lymph nodes and validated against a histological gold standard. Results are shown illustrating the variation in optical properties between cancerous and healthy tissue.
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U2 - 10.1007/978-3-642-04271-3_80
DO - 10.1007/978-3-642-04271-3_80
M3 - Conference contribution
C2 - 20426168
AN - SCOPUS:79551684557
SN - 3642042708
SN - 9783642042706
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 657
EP - 664
BT - Medical Image Computing and Computer-Assisted Intervention - MICCAI2009 - 12th International Conference, Proceedings
T2 - 12th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2009
Y2 - 20 September 2009 through 24 September 2009
ER -