Mapping tissue optical attenuation to identify cancer using optical coherence tomography

Robert A. McLaughlin, Loretta Scolaro, Peter Robbins, Christobel Saunders, Steven L. Jacques, David D. Sampson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

17 Scopus citations

Abstract

The lymphatic system is a common route for the spread of cancer and the identification of lymph node metastases is a key task during cancer surgery. This paper demonstrates the use of optical coherence tomography to construct parametric images of lymph nodes. It describes a method to automatically estimate the optical attenuation coefficient of tissue. By mapping the optical attenuation coefficient at each location in the scan, it is possible to construct a parametric image indicating variations in tissue type. The algorithm is applied to ex vivo samples of human axillary lymph nodes and validated against a histological gold standard. Results are shown illustrating the variation in optical properties between cancerous and healthy tissue.

Original languageEnglish (US)
Title of host publicationMedical Image Computing and Computer-Assisted Intervention - MICCAI2009 - 12th International Conference, Proceedings
Pages657-664
Number of pages8
EditionPART 2
DOIs
StatePublished - Dec 1 2009
Event12th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2009 - London, United Kingdom
Duration: Sep 20 2009Sep 24 2009

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
NumberPART 2
Volume5762 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other12th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2009
CountryUnited Kingdom
CityLondon
Period9/20/099/24/09

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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  • Cite this

    McLaughlin, R. A., Scolaro, L., Robbins, P., Saunders, C., Jacques, S. L., & Sampson, D. D. (2009). Mapping tissue optical attenuation to identify cancer using optical coherence tomography. In Medical Image Computing and Computer-Assisted Intervention - MICCAI2009 - 12th International Conference, Proceedings (PART 2 ed., pp. 657-664). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 5762 LNCS, No. PART 2). https://doi.org/10.1007/978-3-642-04271-3_80