TY - JOUR
T1 - Mapping the growth hormone-Stat5b-IGF-I transcriptional circuit
AU - Rotwein, Peter
N1 - Funding Information:
Grant support comes from the National Institutes of Health (R01 DK069703). I thank current and past laboratory colleagues for their insights and efforts in developing our understanding of IGF-I gene regulation, and gratefully acknowledge Dr William H. Daughaday, who taught me the wonders of the somatomedins. I apologize to colleagues whose work was not cited because of page limitations.
PY - 2012/4
Y1 - 2012/4
N2 - Growth hormone (GH) and insulin-like growth factor-I (IGF-I) exert powerful influences on somatic growth, metabolism, and tissue repair, and have been implicated in aging and carcinogenesis. Since the formulation of the somatomedin hypothesis over 50 years ago, GH and IGF-I have been linked intimately to one another. Recent studies have established that GH potently stimulates IGF-I gene transcription, and through this mechanism controls production of IGF-I. A key mediator of the GH-IGF-I biosynthetic pathway is the latent transcription factor Stat5b. This review summarizes the potentially complex mechanistic relationship between GH action, Stat5b, and IGF-I gene activation, and suggests that Stat5b may have a broad role in mediating IGF-I gene regulation in response to diverse physiological inputs.
AB - Growth hormone (GH) and insulin-like growth factor-I (IGF-I) exert powerful influences on somatic growth, metabolism, and tissue repair, and have been implicated in aging and carcinogenesis. Since the formulation of the somatomedin hypothesis over 50 years ago, GH and IGF-I have been linked intimately to one another. Recent studies have established that GH potently stimulates IGF-I gene transcription, and through this mechanism controls production of IGF-I. A key mediator of the GH-IGF-I biosynthetic pathway is the latent transcription factor Stat5b. This review summarizes the potentially complex mechanistic relationship between GH action, Stat5b, and IGF-I gene activation, and suggests that Stat5b may have a broad role in mediating IGF-I gene regulation in response to diverse physiological inputs.
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U2 - 10.1016/j.tem.2012.01.001
DO - 10.1016/j.tem.2012.01.001
M3 - Review article
C2 - 22361342
AN - SCOPUS:84858752729
SN - 1043-2760
VL - 23
SP - 186
EP - 193
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 4
ER -