Mapping the genes for the acoustic startle response (ASR) and prepulse inhibition of the ASR in the BXD recombinant inbred series: Effect of high-frequency hearing loss and cochlear pathology

Robert Hitzemann, James Bell, Erik Rasmussen, James McCaughran

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Scopus citations

Abstract

The past decade has witnessed some remarkable advances in detecting and mapping the chromosomal position of genes associated with behavioral phenotypes. It is now clear that behavioral quantitative trait loci (QTLs) can be reproducibly mapped, with high log of odds (LOD) scores (Flint et al., 1995; Gershenfeld et al., 1997; Koyner et al., 2000), and that these QTL intervals can be reduced to 1 to 2 cM (Talbot et al., 1999; Demarest et al., 2000). Complimenting these advances, we now have a draft of the human genome and the mouse genome project should be completed soon. From these perspectives, QTL analyses will soon focus on selecting candidate genes within small QTL intervals and on determining which polymorphisms in the candidates selected are functionally relevant.

Original languageEnglish (US)
Title of host publicationHandbook of Mouse Auditory Research
Subtitle of host publicationFrom Behavior to Molecular Biology
PublisherCRC Press
Pages441-455
Number of pages15
ISBN (Electronic)9781420038736
ISBN (Print)0849323282, 9780849323287
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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    Hitzemann, R., Bell, J., Rasmussen, E., & McCaughran, J. (2001). Mapping the genes for the acoustic startle response (ASR) and prepulse inhibition of the ASR in the BXD recombinant inbred series: Effect of high-frequency hearing loss and cochlear pathology. In Handbook of Mouse Auditory Research: From Behavior to Molecular Biology (pp. 441-455). CRC Press.