Mapping of Macular Substructures with Optical Coherence Tomography for Glaucoma Diagnosis

Ou Tan, Gisèle Li, Ake Tzu Hui Lu, Rohit Varma, David Huang

Research output: Contribution to journalArticle

265 Citations (Scopus)

Abstract

Purpose: To use optical coherence tomography (OCT) to identify the specific retinal layers and macular regions damaged in glaucoma. Design: Observational cross-sectional study. Participants: One hundred forty-nine participants in the Advanced Imaging for Glaucoma Study, divided into 3 groups: normal (N) perimetric glaucoma (PG), and glaucoma suspect and preperimetric glaucoma (GSPPG) with 44, 73, and 29 persons, respectively. Methods: The Zeiss Stratus OCT system (Carl Zeiss Meditec, Inc., Dublin, CA) was used to map the macula over a 6-mm diameter and to scan the circumpapillary nerve fiber layer (cpNFL). The macular OCT images were exported for automatic segmentation using software developed by the authors. The thickness of the macular nerve fiber layer (mNFL), ganglion cell layer (mGCL), inner plexiform layer (mIPL), inner nuclear layer (mINL), outer retinal layer (mORL), and total retinal thickness were measured. Thickness measurements of GSPPG and PG eyes were compared with those of N eyes. The ability to differentiate between GSPPG and PG eyes against N eyes was assessed by fractional loss, standardized deviation, and the area under the receiver operating characteristic curve. Main Outcome Measures: Area-weighted average thicknesses of retinal sublayers in the macula. Results: The mNFL, mGCL, mIPL, and mINL were significantly (P

Original languageEnglish (US)
Pages (from-to)949-956
Number of pages8
JournalOphthalmology
Volume115
Issue number6
DOIs
StatePublished - Jun 2008
Externally publishedYes

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Optical Coherence Tomography
Glaucoma
Ocular Hypertension
Nerve Fibers
Ganglia
ROC Curve
Software
Cross-Sectional Studies
Outcome Assessment (Health Care)

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Mapping of Macular Substructures with Optical Coherence Tomography for Glaucoma Diagnosis. / Tan, Ou; Li, Gisèle; Lu, Ake Tzu Hui; Varma, Rohit; Huang, David.

In: Ophthalmology, Vol. 115, No. 6, 06.2008, p. 949-956.

Research output: Contribution to journalArticle

Tan, Ou ; Li, Gisèle ; Lu, Ake Tzu Hui ; Varma, Rohit ; Huang, David. / Mapping of Macular Substructures with Optical Coherence Tomography for Glaucoma Diagnosis. In: Ophthalmology. 2008 ; Vol. 115, No. 6. pp. 949-956.
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