Abstract
Hemispheric asymmetry is a cardinal feature of human brain organization. Altered brain asymmetry has also been linked to some cognitive and neuropsychiatric disorders. Here the ENIGMA consortium presents the largest ever analysis of cerebral cortical asymmetry and its variability across individuals. Cortical thickness and surface area were assessed in MRI scans of 17,141 healthy individuals from 99 datasets worldwide. Results revealed widespread asymmetries at both hemispheric and regional levels, with a generally thicker cortex but smaller surface area in the left hemisphere relative to the right. Regionally, asymmetries of cortical thickness and/or surface area were found in the inferior frontal gyrus, transverse temporal gyrus, parahippocampal gyrus, and entorhinal cortex. These regions are involved in lateralized functions, including language and visuospatial processing. In addition to population-level asymmetries, variability in brain asymmetry was related to sex, age, and brain size (indexed by intracranial volume). Interestingly, we did not find significant associations between asymmetries and handedness. Finally, with two independent pedigree datasets (N = 1,443 and 1,113, respectively), we found several asymmetries showing modest but highly reliable heritability. The structural asymmetries identified, and their variabilities and heritability provide a reference resource for future studies on the genetic basis of brain asymmetry and altered laterality in cognitive, neurological, and psychiatric disorders. Significance Statement Left-right asymmetry is a key feature of the human brain's structure and function. It remains unclear which cortical regions are asymmetrical on average in the population, and how biological factors such as age, sex and genetic variation affect these asymmetries. Here we describe by far the largest ever study of cerebral cortical brain asymmetry, based on data from 17,141 participants. We found a global anterior-posterior 'torque' pattern in cortical thickness, together with various regional asymmetries at the population level, which have not been previously described, as well as effects of age, sex, and heritability estimates. From these data, we have created an on-line resource that will serve future studies of human brain anatomy in health and disease.
| Original language | English (US) |
|---|---|
| Journal | Unknown Journal |
| DOIs | |
| State | Published - Oct 1 2017 |
Keywords
- brain asymmetry
- cortical thickness
- lateralization
- meta-analysis
- surface area
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Agricultural and Biological Sciences(all)
- Immunology and Microbiology(all)
- Neuroscience(all)
- Pharmacology, Toxicology and Pharmaceutics(all)
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Mapping Cortical Brain Asymmetry in 17,141 Healthy Individuals Worldwide via the ENIGMA Consortium. / Kong, Xiang Zhen; Mathias, Samuel R.; Guadalupe, Tulio; Abé, Christoph; Agartz, Ingrid; Akudjedu, Theophilus N.; Andre, Aleman; Saud, Alhusaini; Allen, Nicholas B.; Ames, David; Andreassen, Ole A.; Arias Vasquez, Alejandro; Armstrong, Nicola J.; Bergo, Felipe; Bastin, Mark E.; Batalla, Albert; Bauer, Jochen; Baune, Bernhard T.; Baur, Ramona; Biederman, Joseph; Blaine, Sara K.; Boedhoe, Premika; Bøen, Erlend; Bose, Anushree; Bralten, Janita; Brandeis, Daniel; Brem, Silvia; Brodaty, Henry; Bröhl, Henrieke; Brooks, Samantha J.; Buitelaar, Jan; Bürger, Christian; Bülow, Robin; Calhoun, Vince; Calvo, Anna; Canales-Rodríguez, Erick Jorge; Canive, Jose M.; Cannon, Dara M.; Caparelli, Elisabeth C.; Castellanos, Francisco X.; Cavalleri, Gianpiero L.; Cendes, Fernando; Chaim-Avancini, Tiffany Moukbel; Chantiluke, Kaylita; Chen, Qun lin; Chen, Xiayu; Cheng, Yuqi; Christakou, Anastasia; Clark, Vincent P.; Coghill, David; Connolly, Colm G.; Conzelmann, Annette; Cόrdova-Palomera, Aldo; Cousijn, Janna; Crow, Tim; Cubillo, Ana; Dannlowski, Udo; de Bruttopilo, Sara Ambrosino; de Zeeuw, Patrick; Deary, Ian J.; Delanty, Norman; Demeter, Damion V.; Martino, Adriana Di; Dickie, Erin W.; Dietsche, Bruno; Doan, N. Trung; Doherty, Colin P.; Doyle, Alysa; Durston, Sarah; Earl, Eric; Ehrlich, Stefan; Ekman, Carl Johan; Elvsåshagen, Torbjørn; Epstein, Jeffery N.; Fair, Damien A.; Faraone, Stephen; Fatouros-Bergman, Helena; Fernndez, Guillen; Busatto Filho, Geraldo; Flyckt, Lena; Forster, Katharina; Jean-Paul, Fouche; Foxe, John J.; Fuentes-Claramonte, Paola; Fullerton, Janice; Garavan, Hugh; Garcia, Danielle do Santos; Gotlib, Ian H.; Goudriaan, Anna E.; Jorgen Grabe, Hans; Groenewold, Nynke A.; Grotegerd, Dominik; Gruber, Oliver; Gurholt, Tiril; Haavik, Jan; Hahn, Tim; Hansell, Narelle K.; Harris, Mathew A.; Hartman, Catharina; Hernandez, Maria del Carmen Valdes; Heslenfeld, Dirk; Hester, Robert; Hibar, Derrek Paul; Ho, Beng Choon; Ho, Tiffany C.; Hoekstra, Pieter J.; van Holst, Ruth J.; Hoogman, Martine; Hovik, Marie F.; Howells, Fleur M.; Hugdahl, Kenneth; Huyser, Chaim; Ingvar, Martind; Irwin, Lourdes; Ishikawa, Akari; James, Anthony; Jahanshad, Neda; Jernigan, Terry L.; Jonsson, Erik G.; Kahler, Claas; Kaleda, Vasily; Kelly, Clare; Kerich, Michael; Keshavan, Matcheri S.; Khadka, Sabin; Kircher, Tilo; Kohls, Gregor; Konrad, Kerstin; Korucuoglu, Ozlem; Kramer, Bernd; Krug, Axel; Kwon, Jun Soo; Lambregts-Rommelse, Nanda; Landen, Mikael; Lazaro, Luisa; Lebedeva, Irina; Lenroot, Rhoshel; Lesch, Klaus Peter; Li, Qinqin; Lim, Kelvin O.; Liu, Jia; Lochner, Christine; London, Edythe D.; Lonning, Vera; Lorenzetti, Valentina; Luciano, Michelle; Luijten, Maartje; Lundervold, Astri J.; Mackey, Scott; MacMaster, Frank P.; Maingault, Sophie; Malpas, Charles B.; Malt, Ulrik F.; Mataix-Cols, David; Martin-Santos, Rocio; Mayer, Andrew R.; McCarthy, Hazel; Mitchell, Philip B.; Mueller, Bryon A.; Maniega, Susana Munoz; Mazoyer, Bernard; McDonald, Colm; McLellan, Quinn; McMahon, Katie L.; McPhilemy, Genevieve; Momenan, Reza; Morales, Angelica M.; Narayanaswamy, Janardhanan C.; Moreira, Jose Carlos Vasques; Nerland, Stener; Nestor, Liam; Nigg, Joel; Nordvik, Jan Egil; Novotny, Stephanie; Oberwelland, Eileen; O'Gorman, Ruth L.; Oosterlaan, Jaap; Oranje, Bob; Orr, Catherine; Overs, Bronwyn; Pauli, Paul; Paulus, Martin; Plessen, Kerstin; von Polier, Georg G.; Pomarol-Clotet, Edith; Qiu, Jiang; Radua, Joaquim; Ramos-Quiroga, Josep Antoni; Reddy, Y. C.Janardhan; Reif, Andreas; Roberts, Gloria; Rosa, Pedro; Rubia, Katya; Sacchet, Matthew D.; Sachdev, Perminder S.; Salvador, Raymond; Schmaal, Lianne; Schweren, Lisanne; Seidman, Larry; Seitz, Jochen; Serpa, Mauricio Henriques; Shaw, Philip; Shumskaya, Elena; Silk, Timothy J.; Simmons, Alan N.; Simulionyte, Egle; Sinha, Rajita; Sjoerds, Zsuzsika; Smelror, Runar Elle; Soliva, Joan Carlos; Solowij, Nadia; Sponheim, Scott R.; Stein, Dan J.; Stein, Elliot A.; Stevens, Michael; Strike, Lachlan T.; Sudre, Gustavo; Sui, Jing; Tamm, Leanne; Temmingh, Hendrik S.; Thoma, Robert J.; Tomyshev, Alexander; Tronchin, Giulia; Turner, Jessica; Uhlmann, Anne; van Erp, Theo G.M.; van den Heuvel, Odile; van der Meer, Dennis; van Eijk, Liza; Vance, Alasdair; Veer, Ilya M.; Veltman, Dick J.; Venkatasubramanian, Ganesan; Vilarroya, Oscar; Vives-Gilabert, Yolanda; Voineskos, Aristotle N.; Volzke, Henry; Vuletic, Daniella; Walitza, Susanne; Walter, Henrik; Walton, Esther; Wardlaw, Joanna M.; Wen, Wei; Westlye, Lars T.; Whelan, Christopher D.; White, Tonya; Wiers, Reinout W.; Wright, Margaret J.; Wittfeld, Katharina; Yang, Tony T.; Yasuda, Clarissa L.; Yoncheva, Yuliya; Yucel, Murat; Yun, Je Yeon; Zanetti, Marcus Vinicius; Zhen, Zonglei; Zhu, Xing xing; Ziegler, Georg C.; Zierhut, Kathrin; de Zubicaray, Greig I.; Zwiers, Marcel; de Zubicaray, Greig I.; Glahn, David C.; Franke, Barbara; Crivello, Fabrice; Tzourio-Mazoyer, Nathalie; Fisher, Simon E.; Thompson, Paul M.; Francks, Clyde; Farde, Lars; Engberg, Goran; Erhardt, Sophie; Cervenka, Simon; Schwieler, Lilly; Piehl, Fredrik; Collste, Karin; Victorsson, Pauliina; Malmqvist, Anna; Hedberg, Mikael; Orhan, Funda.
In: Unknown Journal, 01.10.2017.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Mapping Cortical Brain Asymmetry in 17,141 Healthy Individuals Worldwide via the ENIGMA Consortium
AU - Kong, Xiang Zhen
AU - Mathias, Samuel R.
AU - Guadalupe, Tulio
AU - Abé, Christoph
AU - Agartz, Ingrid
AU - Akudjedu, Theophilus N.
AU - Andre, Aleman
AU - Saud, Alhusaini
AU - Allen, Nicholas B.
AU - Ames, David
AU - Andreassen, Ole A.
AU - Arias Vasquez, Alejandro
AU - Armstrong, Nicola J.
AU - Bergo, Felipe
AU - Bastin, Mark E.
AU - Batalla, Albert
AU - Bauer, Jochen
AU - Baune, Bernhard T.
AU - Baur, Ramona
AU - Biederman, Joseph
AU - Blaine, Sara K.
AU - Boedhoe, Premika
AU - Bøen, Erlend
AU - Bose, Anushree
AU - Bralten, Janita
AU - Brandeis, Daniel
AU - Brem, Silvia
AU - Brodaty, Henry
AU - Bröhl, Henrieke
AU - Brooks, Samantha J.
AU - Buitelaar, Jan
AU - Bürger, Christian
AU - Bülow, Robin
AU - Calhoun, Vince
AU - Calvo, Anna
AU - Canales-Rodríguez, Erick Jorge
AU - Canive, Jose M.
AU - Cannon, Dara M.
AU - Caparelli, Elisabeth C.
AU - Castellanos, Francisco X.
AU - Cavalleri, Gianpiero L.
AU - Cendes, Fernando
AU - Chaim-Avancini, Tiffany Moukbel
AU - Chantiluke, Kaylita
AU - Chen, Qun lin
AU - Chen, Xiayu
AU - Cheng, Yuqi
AU - Christakou, Anastasia
AU - Clark, Vincent P.
AU - Coghill, David
AU - Connolly, Colm G.
AU - Conzelmann, Annette
AU - Cόrdova-Palomera, Aldo
AU - Cousijn, Janna
AU - Crow, Tim
AU - Cubillo, Ana
AU - Dannlowski, Udo
AU - de Bruttopilo, Sara Ambrosino
AU - de Zeeuw, Patrick
AU - Deary, Ian J.
AU - Delanty, Norman
AU - Demeter, Damion V.
AU - Martino, Adriana Di
AU - Dickie, Erin W.
AU - Dietsche, Bruno
AU - Doan, N. Trung
AU - Doherty, Colin P.
AU - Doyle, Alysa
AU - Durston, Sarah
AU - Earl, Eric
AU - Ehrlich, Stefan
AU - Ekman, Carl Johan
AU - Elvsåshagen, Torbjørn
AU - Epstein, Jeffery N.
AU - Fair, Damien A.
AU - Faraone, Stephen
AU - Fatouros-Bergman, Helena
AU - Fernndez, Guillen
AU - Busatto Filho, Geraldo
AU - Flyckt, Lena
AU - Forster, Katharina
AU - Jean-Paul, Fouche
AU - Foxe, John J.
AU - Fuentes-Claramonte, Paola
AU - Fullerton, Janice
AU - Garavan, Hugh
AU - Garcia, Danielle do Santos
AU - Gotlib, Ian H.
AU - Goudriaan, Anna E.
AU - Jorgen Grabe, Hans
AU - Groenewold, Nynke A.
AU - Grotegerd, Dominik
AU - Gruber, Oliver
AU - Gurholt, Tiril
AU - Haavik, Jan
AU - Hahn, Tim
AU - Hansell, Narelle K.
AU - Harris, Mathew A.
AU - Hartman, Catharina
AU - Hernandez, Maria del Carmen Valdes
AU - Heslenfeld, Dirk
AU - Hester, Robert
AU - Hibar, Derrek Paul
AU - Ho, Beng Choon
AU - Ho, Tiffany C.
AU - Hoekstra, Pieter J.
AU - van Holst, Ruth J.
AU - Hoogman, Martine
AU - Hovik, Marie F.
AU - Howells, Fleur M.
AU - Hugdahl, Kenneth
AU - Huyser, Chaim
AU - Ingvar, Martind
AU - Irwin, Lourdes
AU - Ishikawa, Akari
AU - James, Anthony
AU - Jahanshad, Neda
AU - Jernigan, Terry L.
AU - Jonsson, Erik G.
AU - Kahler, Claas
AU - Kaleda, Vasily
AU - Kelly, Clare
AU - Kerich, Michael
AU - Keshavan, Matcheri S.
AU - Khadka, Sabin
AU - Kircher, Tilo
AU - Kohls, Gregor
AU - Konrad, Kerstin
AU - Korucuoglu, Ozlem
AU - Kramer, Bernd
AU - Krug, Axel
AU - Kwon, Jun Soo
AU - Lambregts-Rommelse, Nanda
AU - Landen, Mikael
AU - Lazaro, Luisa
AU - Lebedeva, Irina
AU - Lenroot, Rhoshel
AU - Lesch, Klaus Peter
AU - Li, Qinqin
AU - Lim, Kelvin O.
AU - Liu, Jia
AU - Lochner, Christine
AU - London, Edythe D.
AU - Lonning, Vera
AU - Lorenzetti, Valentina
AU - Luciano, Michelle
AU - Luijten, Maartje
AU - Lundervold, Astri J.
AU - Mackey, Scott
AU - MacMaster, Frank P.
AU - Maingault, Sophie
AU - Malpas, Charles B.
AU - Malt, Ulrik F.
AU - Mataix-Cols, David
AU - Martin-Santos, Rocio
AU - Mayer, Andrew R.
AU - McCarthy, Hazel
AU - Mitchell, Philip B.
AU - Mueller, Bryon A.
AU - Maniega, Susana Munoz
AU - Mazoyer, Bernard
AU - McDonald, Colm
AU - McLellan, Quinn
AU - McMahon, Katie L.
AU - McPhilemy, Genevieve
AU - Momenan, Reza
AU - Morales, Angelica M.
AU - Narayanaswamy, Janardhanan C.
AU - Moreira, Jose Carlos Vasques
AU - Nerland, Stener
AU - Nestor, Liam
AU - Nigg, Joel
AU - Nordvik, Jan Egil
AU - Novotny, Stephanie
AU - Oberwelland, Eileen
AU - O'Gorman, Ruth L.
AU - Oosterlaan, Jaap
AU - Oranje, Bob
AU - Orr, Catherine
AU - Overs, Bronwyn
AU - Pauli, Paul
AU - Paulus, Martin
AU - Plessen, Kerstin
AU - von Polier, Georg G.
AU - Pomarol-Clotet, Edith
AU - Qiu, Jiang
AU - Radua, Joaquim
AU - Ramos-Quiroga, Josep Antoni
AU - Reddy, Y. C.Janardhan
AU - Reif, Andreas
AU - Roberts, Gloria
AU - Rosa, Pedro
AU - Rubia, Katya
AU - Sacchet, Matthew D.
AU - Sachdev, Perminder S.
AU - Salvador, Raymond
AU - Schmaal, Lianne
AU - Schweren, Lisanne
AU - Seidman, Larry
AU - Seitz, Jochen
AU - Serpa, Mauricio Henriques
AU - Shaw, Philip
AU - Shumskaya, Elena
AU - Silk, Timothy J.
AU - Simmons, Alan N.
AU - Simulionyte, Egle
AU - Sinha, Rajita
AU - Sjoerds, Zsuzsika
AU - Smelror, Runar Elle
AU - Soliva, Joan Carlos
AU - Solowij, Nadia
AU - Sponheim, Scott R.
AU - Stein, Dan J.
AU - Stein, Elliot A.
AU - Stevens, Michael
AU - Strike, Lachlan T.
AU - Sudre, Gustavo
AU - Sui, Jing
AU - Tamm, Leanne
AU - Temmingh, Hendrik S.
AU - Thoma, Robert J.
AU - Tomyshev, Alexander
AU - Tronchin, Giulia
AU - Turner, Jessica
AU - Uhlmann, Anne
AU - van Erp, Theo G.M.
AU - van den Heuvel, Odile
AU - van der Meer, Dennis
AU - van Eijk, Liza
AU - Vance, Alasdair
AU - Veer, Ilya M.
AU - Veltman, Dick J.
AU - Venkatasubramanian, Ganesan
AU - Vilarroya, Oscar
AU - Vives-Gilabert, Yolanda
AU - Voineskos, Aristotle N.
AU - Volzke, Henry
AU - Vuletic, Daniella
AU - Walitza, Susanne
AU - Walter, Henrik
AU - Walton, Esther
AU - Wardlaw, Joanna M.
AU - Wen, Wei
AU - Westlye, Lars T.
AU - Whelan, Christopher D.
AU - White, Tonya
AU - Wiers, Reinout W.
AU - Wright, Margaret J.
AU - Wittfeld, Katharina
AU - Yang, Tony T.
AU - Yasuda, Clarissa L.
AU - Yoncheva, Yuliya
AU - Yucel, Murat
AU - Yun, Je Yeon
AU - Zanetti, Marcus Vinicius
AU - Zhen, Zonglei
AU - Zhu, Xing xing
AU - Ziegler, Georg C.
AU - Zierhut, Kathrin
AU - de Zubicaray, Greig I.
AU - Zwiers, Marcel
AU - de Zubicaray, Greig I.
AU - Glahn, David C.
AU - Franke, Barbara
AU - Crivello, Fabrice
AU - Tzourio-Mazoyer, Nathalie
AU - Fisher, Simon E.
AU - Thompson, Paul M.
AU - Francks, Clyde
AU - Farde, Lars
AU - Engberg, Goran
AU - Erhardt, Sophie
AU - Cervenka, Simon
AU - Schwieler, Lilly
AU - Piehl, Fredrik
AU - Collste, Karin
AU - Victorsson, Pauliina
AU - Malmqvist, Anna
AU - Hedberg, Mikael
AU - Orhan, Funda
N1 - Publisher Copyright: The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2017/10/1
Y1 - 2017/10/1
N2 - Hemispheric asymmetry is a cardinal feature of human brain organization. Altered brain asymmetry has also been linked to some cognitive and neuropsychiatric disorders. Here the ENIGMA consortium presents the largest ever analysis of cerebral cortical asymmetry and its variability across individuals. Cortical thickness and surface area were assessed in MRI scans of 17,141 healthy individuals from 99 datasets worldwide. Results revealed widespread asymmetries at both hemispheric and regional levels, with a generally thicker cortex but smaller surface area in the left hemisphere relative to the right. Regionally, asymmetries of cortical thickness and/or surface area were found in the inferior frontal gyrus, transverse temporal gyrus, parahippocampal gyrus, and entorhinal cortex. These regions are involved in lateralized functions, including language and visuospatial processing. In addition to population-level asymmetries, variability in brain asymmetry was related to sex, age, and brain size (indexed by intracranial volume). Interestingly, we did not find significant associations between asymmetries and handedness. Finally, with two independent pedigree datasets (N = 1,443 and 1,113, respectively), we found several asymmetries showing modest but highly reliable heritability. The structural asymmetries identified, and their variabilities and heritability provide a reference resource for future studies on the genetic basis of brain asymmetry and altered laterality in cognitive, neurological, and psychiatric disorders. Significance Statement Left-right asymmetry is a key feature of the human brain's structure and function. It remains unclear which cortical regions are asymmetrical on average in the population, and how biological factors such as age, sex and genetic variation affect these asymmetries. Here we describe by far the largest ever study of cerebral cortical brain asymmetry, based on data from 17,141 participants. We found a global anterior-posterior 'torque' pattern in cortical thickness, together with various regional asymmetries at the population level, which have not been previously described, as well as effects of age, sex, and heritability estimates. From these data, we have created an on-line resource that will serve future studies of human brain anatomy in health and disease.
AB - Hemispheric asymmetry is a cardinal feature of human brain organization. Altered brain asymmetry has also been linked to some cognitive and neuropsychiatric disorders. Here the ENIGMA consortium presents the largest ever analysis of cerebral cortical asymmetry and its variability across individuals. Cortical thickness and surface area were assessed in MRI scans of 17,141 healthy individuals from 99 datasets worldwide. Results revealed widespread asymmetries at both hemispheric and regional levels, with a generally thicker cortex but smaller surface area in the left hemisphere relative to the right. Regionally, asymmetries of cortical thickness and/or surface area were found in the inferior frontal gyrus, transverse temporal gyrus, parahippocampal gyrus, and entorhinal cortex. These regions are involved in lateralized functions, including language and visuospatial processing. In addition to population-level asymmetries, variability in brain asymmetry was related to sex, age, and brain size (indexed by intracranial volume). Interestingly, we did not find significant associations between asymmetries and handedness. Finally, with two independent pedigree datasets (N = 1,443 and 1,113, respectively), we found several asymmetries showing modest but highly reliable heritability. The structural asymmetries identified, and their variabilities and heritability provide a reference resource for future studies on the genetic basis of brain asymmetry and altered laterality in cognitive, neurological, and psychiatric disorders. Significance Statement Left-right asymmetry is a key feature of the human brain's structure and function. It remains unclear which cortical regions are asymmetrical on average in the population, and how biological factors such as age, sex and genetic variation affect these asymmetries. Here we describe by far the largest ever study of cerebral cortical brain asymmetry, based on data from 17,141 participants. We found a global anterior-posterior 'torque' pattern in cortical thickness, together with various regional asymmetries at the population level, which have not been previously described, as well as effects of age, sex, and heritability estimates. From these data, we have created an on-line resource that will serve future studies of human brain anatomy in health and disease.
KW - brain asymmetry
KW - cortical thickness
KW - lateralization
KW - meta-analysis
KW - surface area
UR - http://www.scopus.com/inward/record.url?scp=85095644535&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85095644535&partnerID=8YFLogxK
U2 - 10.1101/196634
DO - 10.1101/196634
M3 - Article
AN - SCOPUS:85095644535
JO - Indian Journal of Rheumatology
JF - Indian Journal of Rheumatology
SN - 0973-3698
ER -