Mapping a gene for adult-onset primary open-angle glaucoma to chromosome 3q

M. K. Wirtz, J. R. Samples, P. L. Kramer, K. Rust, J. R. Topinka, J. Yount, R. D. Koler, T. S. Acott

Research output: Contribution to journalArticlepeer-review

189 Scopus citations

Abstract

Glaucoma is the third-leading cause of blindness in the world, affecting > 13.5 million people. Adult-onset primary open-angle glaucoma (POAG) is the most common form of glaucoma in the United States. We present a family in which adult-onset POAG is inherited as an autosomal dominant trait. Twelve affected family members were identified from 44 at-risk individuals. The disease-causing gene was mapped to chromosome 3q21-24, with analysis of recombinant haplotypes suggesting a total inclusion region of 11.1 cM between markers D3S3637 and D3S1744. This is the first report of mapping of an adult- onset POAG gene to chromosome 3q, gene symbol GLC1C.

Original languageEnglish (US)
Pages (from-to)296-304
Number of pages9
JournalAmerican Journal of Human Genetics
Volume60
Issue number2
StatePublished - Feb 1997

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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