TY - JOUR
T1 - Myocardial T1 mapping and determination of partition coefficients at 3 tesla
T2 - Comparison between gadobenate dimeglumine and gadofosveset trisodium
AU - Nacif, Marcelo Souto
AU - Raman, Fabio S.
AU - Gai, Neville
AU - Jones, Jacquin
AU - Van Der Geest, Rob J.
AU - Sibley, Christopher T.
AU - Liu, Songtao
AU - Bluemke, David A.
N1 - Publisher Copyright:
© Colégio Brasileiro de Radiologia e Diagnóstico por Imagem.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Objective: To compare an albumin-bound gadolinium chelate (gadofosveset trisodium) and an extracellular contrast agent (gado-benate dimeglumine), in terms of their effects on myocardial longitudinal (T1) relaxation time and partition coefficient. Materials and Methods: Study subjects underwent two imaging sessions for T1 mapping at 3 tesla with a modified look-locker inversion recovery (MOLLI) pulse sequence to obtain one pre-contrast T1 map and two post-contrast T1 maps (mean 15 and 21 min, respectively). The partition coefficient was calculated as ΔR1myocardium/ΔR1blood, where R1 is 1/T1. Results: A total of 252 myocardial and blood pool T1 values were obtained in 21 healthy subjects. After gadolinium administration, the myocardial T1 was longer for gadofosveset than for gadobenate, the mean difference between the two contrast agents being −7.6 ± 60 ms (p = 0.41). The inverse was true for the blood pool T1, which was longer for gadobenate than for gadofosveset, the mean difference being 56.5 ± 67 ms (p < 0.001). The partition coefficient (λ) was higher for gadobenate than gadofosveset (0.41 vs. 0.33), indicating slower blood pool washout for gadofosveset than for gadobenate. Conclusion: Myocardial T1 times did not differ significantly between gadobenate and gadofosveset. At typical clinical doses of the contrast agents, partition coefficients were significantly lower for the intravascular contrast agent than for the extravascular agent.
AB - Objective: To compare an albumin-bound gadolinium chelate (gadofosveset trisodium) and an extracellular contrast agent (gado-benate dimeglumine), in terms of their effects on myocardial longitudinal (T1) relaxation time and partition coefficient. Materials and Methods: Study subjects underwent two imaging sessions for T1 mapping at 3 tesla with a modified look-locker inversion recovery (MOLLI) pulse sequence to obtain one pre-contrast T1 map and two post-contrast T1 maps (mean 15 and 21 min, respectively). The partition coefficient was calculated as ΔR1myocardium/ΔR1blood, where R1 is 1/T1. Results: A total of 252 myocardial and blood pool T1 values were obtained in 21 healthy subjects. After gadolinium administration, the myocardial T1 was longer for gadofosveset than for gadobenate, the mean difference between the two contrast agents being −7.6 ± 60 ms (p = 0.41). The inverse was true for the blood pool T1, which was longer for gadobenate than for gadofosveset, the mean difference being 56.5 ± 67 ms (p < 0.001). The partition coefficient (λ) was higher for gadobenate than gadofosveset (0.41 vs. 0.33), indicating slower blood pool washout for gadofosveset than for gadobenate. Conclusion: Myocardial T1 times did not differ significantly between gadobenate and gadofosveset. At typical clinical doses of the contrast agents, partition coefficients were significantly lower for the intravascular contrast agent than for the extravascular agent.
KW - Contrast media
KW - Gadolinium
KW - Gadolinium DTPA
KW - Magnetic resonance imaging/methods
KW - Myocardium/pathology
KW - Organometallic compounds
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U2 - 10.1590/0100-3984.2016.0071
DO - 10.1590/0100-3984.2016.0071
M3 - Article
AN - SCOPUS:85043589970
SN - 0100-3984
VL - 51
SP - 13
EP - 19
JO - Radiologia Brasileira
JF - Radiologia Brasileira
IS - 1
ER -