Manipulations of chloride ion concentration in the organ of corti alter outer hair cell electromotility and cochlear amplification

J. Zheng, Y. Zou, A. L. Nuttall, J. Santos-Sacchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

There is evidence that intracellular chloride ions modulate prestin function. This study investigated how chloride ions (Cl-) influence cochlear sensitivity and OHC electromotility. Lowering perilymph Cl- concentration greatly reduced the magnitude of basal turn BM motion and the electrically evoked otoacoustic emissions. These effects could be modulated by tributyltin (TBT, a Cl- ionophore). The results indicate that the electrochemical drive for Cl- is important for normal activity of prestin.

Original languageEnglish (US)
Title of host publicationAuditory Mechanisms
Subtitle of host publicationProcesses and Models - Proceedings of the 9th International Symposium
EditorsAlfred L. Nuttall, Tianying Ren, Peter Gillespie, Karl Grosh, Egbert de Boer
PublisherWorld Scientific Publishing Co. Pte Ltd
Pages107-108
Number of pages2
ISBN (Electronic)9812568247, 9789812568243
StatePublished - 2005
Event9th International Mechanics of Hearing Workshop on Auditory Mechanisms: Processes and Models, MoH 2005 - Portland, United States
Duration: Jul 23 2005Jul 28 2005

Publication series

NameAuditory Mechanisms: Processes and Models - Proceedings of the 9th International Symposium

Conference

Conference9th International Mechanics of Hearing Workshop on Auditory Mechanisms: Processes and Models, MoH 2005
CountryUnited States
CityPortland
Period7/23/057/28/05

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering

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