Management of patients with pancreatic adenocarcinoma: National trends in patient selection, operative management, and use of adjuvant therapy

Skye Mayo, Marta M. Gilson, Joseph M. Herman, John L. Cameron, Hari Nathan, Barish H. Edil, Michael A. Choti, Richard D. Schulick, Christopher L. Wolfgang, Timothy M. Pawlik

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Surgical resection remains the only potentially curative option for patients with pancreatic adenocarcinoma (PAC). Advances in surgical technique and perioperative care have reduced perioperative mortality; however, temporal trends in perioperative morbidity and the use of adjuvant therapy on a population basis remain ill-defined. Using Surveillance, Epidemiology, and End ResultsMedicare data, 2,461 patients with resected PAC were identified from 1991 to 2005. We examined trends in preoperative comorbidity indices, adjuvant treatment, type of pancreatic resection, and changes in morbidity and mortality during 4 time intervals (ie, 19911996, 19972000, 20012003, and 20032005). The majority of patients underwent pancreaticoduodenectomy (n = 1,945; 79%). There was a temporal increase in mean patient age (p <0.05) and the number of patients with multiple preoperative comorbidities (Elixhauser comorbidities

Original languageEnglish (US)
Pages (from-to)33-45
Number of pages13
JournalJournal of the American College of Surgeons
Volume214
Issue number1
DOIs
StatePublished - Jan 2012
Externally publishedYes

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Patient Selection
Adenocarcinoma
Comorbidity
Morbidity
Perioperative Care
Therapeutics
Pancreaticoduodenectomy
Mortality
Epidemiology
Population

ASJC Scopus subject areas

  • Surgery

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Management of patients with pancreatic adenocarcinoma : National trends in patient selection, operative management, and use of adjuvant therapy. / Mayo, Skye; Gilson, Marta M.; Herman, Joseph M.; Cameron, John L.; Nathan, Hari; Edil, Barish H.; Choti, Michael A.; Schulick, Richard D.; Wolfgang, Christopher L.; Pawlik, Timothy M.

In: Journal of the American College of Surgeons, Vol. 214, No. 1, 01.2012, p. 33-45.

Research output: Contribution to journalArticle

Mayo, Skye ; Gilson, Marta M. ; Herman, Joseph M. ; Cameron, John L. ; Nathan, Hari ; Edil, Barish H. ; Choti, Michael A. ; Schulick, Richard D. ; Wolfgang, Christopher L. ; Pawlik, Timothy M. / Management of patients with pancreatic adenocarcinoma : National trends in patient selection, operative management, and use of adjuvant therapy. In: Journal of the American College of Surgeons. 2012 ; Vol. 214, No. 1. pp. 33-45.
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