Management of patients with advanced prostate cancer: Recommendations of the St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) 2015

Silke Gillessen, A. Omlin, G. Attard, J. S. de Bono, E. Efstathiou, K. Fizazi, S. Halabi, P. S. Nelson, O. Sartor, M. R. Smith, H. R. Soule, H. Akaza, T. M. Beer, H. Beltran, A. M. Chinnaiyan, G. Daugaard, I. D. Davis, M. De Santis, C. G. Drake, R. A. EelesS. Fanti, M. E. Gleave, A. Heidenreich, M. Hussain, N. D. James, F. E. Lecouvet, C. J. Logothetis, K. Mastris, S. Nilsson, W. K. Oh, D. Olmos, A. R. Padhani, C. Parker, M. A. Rubin, J. A. Schalken, H. I. Scher, A. Sella, N. D. Shore, E. J. Small, C. N. Sternberg, H. Suzuki, C. J. Sweeney, I. F. Tannock, B. Tombal

    Research output: Contribution to journalArticle

    193 Scopus citations

    Abstract

    The first St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) Expert Panel identified and reviewed the available evidence for the ten most important areas of controversy in advanced prostate cancer (APC) management. The successful registration of several drugs for castration-resistant prostate cancer and the recent studies of chemo-hormonal therapy in men with castration-naïve prostate cancer have led to considerable uncertainty as to the best treatment choices, sequence of treatment options and appropriate patient selection. Management recommendations based on expert opinion, and not based on a critical review of the available evidence, are presented. The various recommendations carried differing degrees of support, as reflected in the wording of the article text and in the detailed voting results recorded in supplementary Material, available at Annals of Oncology online. Detailed decisions on treatment as always will involve consideration of disease extent and location, prior treatments, host factors, patient preferences as well as logistical and economic constraints. Inclusion of men with APC in clinical trials should be encouraged.

    Original languageEnglish (US)
    Pages (from-to)1589-1604
    Number of pages16
    JournalAnnals of Oncology
    Volume26
    Issue number8
    DOIs
    StatePublished - Jan 1 2015

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    Keywords

    • Advanced prostate cancer
    • Castration-naïve prostate cancer
    • Castration-resistant prostate cancer
    • Consensus
    • Therapeutics

    ASJC Scopus subject areas

    • Hematology
    • Oncology

    Cite this

    Gillessen, S., Omlin, A., Attard, G., de Bono, J. S., Efstathiou, E., Fizazi, K., Halabi, S., Nelson, P. S., Sartor, O., Smith, M. R., Soule, H. R., Akaza, H., Beer, T. M., Beltran, H., Chinnaiyan, A. M., Daugaard, G., Davis, I. D., De Santis, M., Drake, C. G., ... Tombal, B. (2015). Management of patients with advanced prostate cancer: Recommendations of the St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) 2015. Annals of Oncology, 26(8), 1589-1604. https://doi.org/10.1093/annonc/mdv257