Management of lymphoma recurrence after allogeneic transplantation

The relevance of graft-versus-lymphoma effect

K. W. Van Besien, M. De Lima, S. A. Giralt, D. F. Moore, I. F. Khouri, G. Rondón, R. Mehra, B. S. Andersson, C. Dyer, K. Cleary, D. Przepiorka, J. L. Gajewski, R. E. Champlin

Research output: Contribution to journalArticle

192 Citations (Scopus)

Abstract

Donor lymphocyte infusions, by virtue of a graft-versus-tumor effect, have been shown to induce remissions in leukemia that recurs after allogeneic bone marrow transplantation. Similar effects have been postulated to contribute to the decreased recurrence rate observed after allogeneic transplantation in non-Hodgkin's lymphoma. This lower recurrence rate may be due to a variety of other mechanisms. We aimed to evaluate the role of graft-versus-lymphoma effects in patients in whom lymphomas recur after allogeneic transplantation. At the time of recurrence, immunosuppressive therapy was withheld. Patients with non-responding disease received an infusion of donor lymphocytes. Patients were observed for response and graft-versus-host disease. Disease in four of nine patients responded to withdrawal of immunosuppressive therapy. A minor response was observed in one of three recipients of donor lymphocyte infusions. Responses were observed among two patients with follicular lymphoma, one with large cell lymphoma and one with lymphoblastic lymphoma. A minor response was observed in a patient with prolymphocytic leukemia/lymphoma. We conclude that withdrawal of immunosuppressive therapy and donor lymphocyte infusion can induce durable remissions in patients with recurrent lymphoma after allogeneic transplantation.

Original languageEnglish (US)
Pages (from-to)977-982
Number of pages6
JournalBone Marrow Transplantation
Volume19
Issue number10
StatePublished - May 2 1997
Externally publishedYes

Fingerprint

Homologous Transplantation
Lymphoma
Transplants
Recurrence
Immunosuppressive Agents
Tissue Donors
Lymphocytes
Prolymphocytic Leukemia
Follicular Lymphoma
Graft vs Host Disease
Bone Marrow Transplantation
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Non-Hodgkin's Lymphoma
Leukemia
Therapeutics
Neoplasms

Keywords

  • Allogeneic transplantation
  • Graft-versus-lymphoma
  • Lymphoma
  • Recurrence

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Van Besien, K. W., De Lima, M., Giralt, S. A., Moore, D. F., Khouri, I. F., Rondón, G., ... Champlin, R. E. (1997). Management of lymphoma recurrence after allogeneic transplantation: The relevance of graft-versus-lymphoma effect. Bone Marrow Transplantation, 19(10), 977-982.

Management of lymphoma recurrence after allogeneic transplantation : The relevance of graft-versus-lymphoma effect. / Van Besien, K. W.; De Lima, M.; Giralt, S. A.; Moore, D. F.; Khouri, I. F.; Rondón, G.; Mehra, R.; Andersson, B. S.; Dyer, C.; Cleary, K.; Przepiorka, D.; Gajewski, J. L.; Champlin, R. E.

In: Bone Marrow Transplantation, Vol. 19, No. 10, 02.05.1997, p. 977-982.

Research output: Contribution to journalArticle

Van Besien, KW, De Lima, M, Giralt, SA, Moore, DF, Khouri, IF, Rondón, G, Mehra, R, Andersson, BS, Dyer, C, Cleary, K, Przepiorka, D, Gajewski, JL & Champlin, RE 1997, 'Management of lymphoma recurrence after allogeneic transplantation: The relevance of graft-versus-lymphoma effect', Bone Marrow Transplantation, vol. 19, no. 10, pp. 977-982.
Van Besien KW, De Lima M, Giralt SA, Moore DF, Khouri IF, Rondón G et al. Management of lymphoma recurrence after allogeneic transplantation: The relevance of graft-versus-lymphoma effect. Bone Marrow Transplantation. 1997 May 2;19(10):977-982.
Van Besien, K. W. ; De Lima, M. ; Giralt, S. A. ; Moore, D. F. ; Khouri, I. F. ; Rondón, G. ; Mehra, R. ; Andersson, B. S. ; Dyer, C. ; Cleary, K. ; Przepiorka, D. ; Gajewski, J. L. ; Champlin, R. E. / Management of lymphoma recurrence after allogeneic transplantation : The relevance of graft-versus-lymphoma effect. In: Bone Marrow Transplantation. 1997 ; Vol. 19, No. 10. pp. 977-982.
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