TY - JOUR
T1 - Management of anticoagulation in patients with prostate cancer receiving enzalutamide
AU - Shatzel, Joseph J.
AU - Daughety, Molly M.
AU - Olson, Sven R.
AU - Beer, Tomasz M.
AU - DeLoughery, Thomas G.
N1 - Publisher Copyright:
Copyright © 2017 American Society of Clinical Oncology. All rights reserved.
PY - 2017/11
Y1 - 2017/11
N2 - Enzalutamide, a novel, oral androgen receptor antagonist used for the treatment of metastatic, castration-resistant prostate cancer, has been shown to improve overall and progression-free survival, prolong time to initiation of chemotherapy, reduce skeletal-related events, and carry a favorable adverse effect profile. Metastatic prostate cancer is a disease of older men, a population with an increased incidence of medical comorbidities warranting anticoagulation. Prostate cancer itself, along with some of its therapies, is also prothrombotic. Enzalutamide interacts with several anticoagulants through various mechanisms, making their concurrent use clinically challenging. As such, complex decisions about anticoagulation in these patients are frequently encountered by treating physicians. In this review, we describe the potential interactions between enzalutamide and various anticoagulants, and suggest management paradigms based on the current body of knowledge for patients with atrial fibrillation, venous thromboembolism, and mechanical heart valves.
AB - Enzalutamide, a novel, oral androgen receptor antagonist used for the treatment of metastatic, castration-resistant prostate cancer, has been shown to improve overall and progression-free survival, prolong time to initiation of chemotherapy, reduce skeletal-related events, and carry a favorable adverse effect profile. Metastatic prostate cancer is a disease of older men, a population with an increased incidence of medical comorbidities warranting anticoagulation. Prostate cancer itself, along with some of its therapies, is also prothrombotic. Enzalutamide interacts with several anticoagulants through various mechanisms, making their concurrent use clinically challenging. As such, complex decisions about anticoagulation in these patients are frequently encountered by treating physicians. In this review, we describe the potential interactions between enzalutamide and various anticoagulants, and suggest management paradigms based on the current body of knowledge for patients with atrial fibrillation, venous thromboembolism, and mechanical heart valves.
UR - http://www.scopus.com/inward/record.url?scp=85037116294&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85037116294&partnerID=8YFLogxK
U2 - 10.1200/JOP.2017.022004
DO - 10.1200/JOP.2017.022004
M3 - Review article
C2 - 29125921
AN - SCOPUS:85037116294
SN - 1554-7477
VL - 13
SP - 720
EP - 727
JO - Journal of oncology practice
JF - Journal of oncology practice
IS - 11
ER -