Management of a recalcitrant candidal chorioretinal abscess

Phoebe Lin, Paula Wynn, Jay M. Stewart

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose: To describe a case of endogenously acquired Candida albicans chorioretinitis that was unresponsive to aggressive local and systemic therapy. Method: Single retrospective case report and review of pertinent literature. A 42-year-old woman with metastatic colon cancer acquired endogenous C. albicans chorioretinitis secondary to total parenteral nutrition after a small-bowel resection. Results: A lesion involving the left fovea progressed despite systemic antifungal therapy with intravenous anidulafungin followed by oral fluconazole, intravenous Ambisome, and 11 total intravitreal injections of either Amphotericin B (5 mg each) or voriconazole (50-100 mg each). The patient underwent pars plana vitrectomy with subfoveal aspiration and removal of infectious material using submacular surgery, resulting in resolution of the infection. Postoperatively the patient's visual acuity was the same as before surgery (20/200 in the left eye). Conclusion: When treating endogenous fungal chorioretinitis, attention should be paid to both systemic treatment that has good intraocular penetration and early local therapy with intravitreal antifungals for sight-threatening lesions. Surgical intervention may also be warranted.

Original languageEnglish (US)
Pages (from-to)280-284
Number of pages5
JournalRetinal Cases and Brief Reports
Volume6
Issue number3
DOIs
StatePublished - Jun 2012
Externally publishedYes

Fingerprint

Chorioretinitis
Abscess
Candida albicans
anidulafungin
Patient Acuity
Intravitreal Injections
Temazepam
Total Parenteral Nutrition
Fluconazole
Vitrectomy
Amphotericin B
Secondary Prevention
Colonic Neoplasms
Visual Acuity
Therapeutics
Infection

Keywords

  • Amphotericin B
  • Candida chorioretinitis
  • Intravitreal antifungal agents
  • Voriconazole

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Management of a recalcitrant candidal chorioretinal abscess. / Lin, Phoebe; Wynn, Paula; Stewart, Jay M.

In: Retinal Cases and Brief Reports, Vol. 6, No. 3, 06.2012, p. 280-284.

Research output: Contribution to journalArticle

Lin, Phoebe ; Wynn, Paula ; Stewart, Jay M. / Management of a recalcitrant candidal chorioretinal abscess. In: Retinal Cases and Brief Reports. 2012 ; Vol. 6, No. 3. pp. 280-284.
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