Mammary gland involution as an immunotherapeutic target for postpartum breast cancer

Jaime Fornetti, Holly A. Martinson, Courtney B. Betts, Traci R. Lyons, Sonali Jindal, Qiuchen Guo, Lisa Coussens, Virginia F. Borges, Pepper Schedin

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Postpartum mammary gland involution has been identified as tumor-promotional and is proposed to contribute to the increased rates of metastasis and poor survival observed in postpartum breast cancer patients. In rodent models, the involuting mammary gland microenvironment is sufficient to induce enhanced tumor cell growth, local invasion, and metastasis. Postpartum involution shares many attributes with wound healing, including upregulation of genes involved in immune responsiveness and infiltration of tissue by immune cells. In rodent models, treatment with non-steroidal anti-inflammatory drugs (NSAIDs) ameliorates the tumor-promotional effects of involution, consistent with the immune milieu of the involuting gland contributing to tumor promotion. Currently, immunotherapy is being investigated as a means of breast cancer treatment with the purpose of identifying ways to enhance anti-tumor immune responses. Here we review evidence for postpartum mammary gland involution being a uniquely defined 'hot-spot' of pro-tumorigenic immune cell infiltration, and propose that immunotherapy should be explored for prevention and treatment of breast cancers that arise in this environment.

Original languageEnglish (US)
Pages (from-to)213-228
Number of pages16
JournalJournal of Mammary Gland Biology and Neoplasia
Volume19
Issue number2
DOIs
StatePublished - 2014

Fingerprint

Human Mammary Glands
Postpartum Period
Breast Neoplasms
Neoplasms
Immunotherapy
Rodentia
Neoplasm Metastasis
Wound Healing
Anti-Inflammatory Agents
Up-Regulation
Therapeutics
Survival
Growth
Pharmaceutical Preparations
Genes

Keywords

  • Chemoprevention
  • Immunotherapy
  • Macrophages
  • Microenvironment

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Mammary gland involution as an immunotherapeutic target for postpartum breast cancer. / Fornetti, Jaime; Martinson, Holly A.; Betts, Courtney B.; Lyons, Traci R.; Jindal, Sonali; Guo, Qiuchen; Coussens, Lisa; Borges, Virginia F.; Schedin, Pepper.

In: Journal of Mammary Gland Biology and Neoplasia, Vol. 19, No. 2, 2014, p. 213-228.

Research output: Contribution to journalArticle

Fornetti, Jaime ; Martinson, Holly A. ; Betts, Courtney B. ; Lyons, Traci R. ; Jindal, Sonali ; Guo, Qiuchen ; Coussens, Lisa ; Borges, Virginia F. ; Schedin, Pepper. / Mammary gland involution as an immunotherapeutic target for postpartum breast cancer. In: Journal of Mammary Gland Biology and Neoplasia. 2014 ; Vol. 19, No. 2. pp. 213-228.
@article{3ae77e4dedc949729786d75172091bd8,
title = "Mammary gland involution as an immunotherapeutic target for postpartum breast cancer",
abstract = "Postpartum mammary gland involution has been identified as tumor-promotional and is proposed to contribute to the increased rates of metastasis and poor survival observed in postpartum breast cancer patients. In rodent models, the involuting mammary gland microenvironment is sufficient to induce enhanced tumor cell growth, local invasion, and metastasis. Postpartum involution shares many attributes with wound healing, including upregulation of genes involved in immune responsiveness and infiltration of tissue by immune cells. In rodent models, treatment with non-steroidal anti-inflammatory drugs (NSAIDs) ameliorates the tumor-promotional effects of involution, consistent with the immune milieu of the involuting gland contributing to tumor promotion. Currently, immunotherapy is being investigated as a means of breast cancer treatment with the purpose of identifying ways to enhance anti-tumor immune responses. Here we review evidence for postpartum mammary gland involution being a uniquely defined 'hot-spot' of pro-tumorigenic immune cell infiltration, and propose that immunotherapy should be explored for prevention and treatment of breast cancers that arise in this environment.",
keywords = "Chemoprevention, Immunotherapy, Macrophages, Microenvironment",
author = "Jaime Fornetti and Martinson, {Holly A.} and Betts, {Courtney B.} and Lyons, {Traci R.} and Sonali Jindal and Qiuchen Guo and Lisa Coussens and Borges, {Virginia F.} and Pepper Schedin",
year = "2014",
doi = "10.1007/s10911-014-9322-z",
language = "English (US)",
volume = "19",
pages = "213--228",
journal = "Journal of Mammary Gland Biology and Neoplasia",
issn = "1083-3021",
publisher = "Springer New York",
number = "2",

}

TY - JOUR

T1 - Mammary gland involution as an immunotherapeutic target for postpartum breast cancer

AU - Fornetti, Jaime

AU - Martinson, Holly A.

AU - Betts, Courtney B.

AU - Lyons, Traci R.

AU - Jindal, Sonali

AU - Guo, Qiuchen

AU - Coussens, Lisa

AU - Borges, Virginia F.

AU - Schedin, Pepper

PY - 2014

Y1 - 2014

N2 - Postpartum mammary gland involution has been identified as tumor-promotional and is proposed to contribute to the increased rates of metastasis and poor survival observed in postpartum breast cancer patients. In rodent models, the involuting mammary gland microenvironment is sufficient to induce enhanced tumor cell growth, local invasion, and metastasis. Postpartum involution shares many attributes with wound healing, including upregulation of genes involved in immune responsiveness and infiltration of tissue by immune cells. In rodent models, treatment with non-steroidal anti-inflammatory drugs (NSAIDs) ameliorates the tumor-promotional effects of involution, consistent with the immune milieu of the involuting gland contributing to tumor promotion. Currently, immunotherapy is being investigated as a means of breast cancer treatment with the purpose of identifying ways to enhance anti-tumor immune responses. Here we review evidence for postpartum mammary gland involution being a uniquely defined 'hot-spot' of pro-tumorigenic immune cell infiltration, and propose that immunotherapy should be explored for prevention and treatment of breast cancers that arise in this environment.

AB - Postpartum mammary gland involution has been identified as tumor-promotional and is proposed to contribute to the increased rates of metastasis and poor survival observed in postpartum breast cancer patients. In rodent models, the involuting mammary gland microenvironment is sufficient to induce enhanced tumor cell growth, local invasion, and metastasis. Postpartum involution shares many attributes with wound healing, including upregulation of genes involved in immune responsiveness and infiltration of tissue by immune cells. In rodent models, treatment with non-steroidal anti-inflammatory drugs (NSAIDs) ameliorates the tumor-promotional effects of involution, consistent with the immune milieu of the involuting gland contributing to tumor promotion. Currently, immunotherapy is being investigated as a means of breast cancer treatment with the purpose of identifying ways to enhance anti-tumor immune responses. Here we review evidence for postpartum mammary gland involution being a uniquely defined 'hot-spot' of pro-tumorigenic immune cell infiltration, and propose that immunotherapy should be explored for prevention and treatment of breast cancers that arise in this environment.

KW - Chemoprevention

KW - Immunotherapy

KW - Macrophages

KW - Microenvironment

UR - http://www.scopus.com/inward/record.url?scp=84905117499&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84905117499&partnerID=8YFLogxK

U2 - 10.1007/s10911-014-9322-z

DO - 10.1007/s10911-014-9322-z

M3 - Article

C2 - 24952477

AN - SCOPUS:84905117499

VL - 19

SP - 213

EP - 228

JO - Journal of Mammary Gland Biology and Neoplasia

JF - Journal of Mammary Gland Biology and Neoplasia

SN - 1083-3021

IS - 2

ER -