Mammalian DNA mismatch repair

Andrew B. Buermeyer, Suzanne M. Deschênes, Sean M. Baker, R. Michael Liskay

Research output: Contribution to journalReview article

371 Scopus citations

Abstract

DNA mismatch repair (MMR) is one of multiple replication, repair, and recombination processes that are required to maintain genomic stability in prokaryotes and eukaryotes. In the wake of the discoveries that hereditary nonpolyposis colorectal cancer (HNPCC) and other human cancers are associated with mutations in MMR genes, intensive efforts are under way to elucidate the biochemical functions of mammalian MutS and MutL homologs, and the consequences of defects in these genes. Genetic studies in cultured mammalian cells and mice are proving to be instrumental in defining the relationship between the functions of MMR in mutation and tumor avoidance. Furthermore, these approaches have raised awareness that MMR homologs contribute to DNA damage surveillance, transcription-coupled repair, and recombinogenic and meiotic processes.

Original languageEnglish (US)
Pages (from-to)533-564
Number of pages32
JournalAnnual Review of Genetics
Volume33
DOIs
StatePublished - 1999

Keywords

  • Genetic instability
  • Hereditary cancer
  • Mice
  • Mutator
  • Tumorigenesis

ASJC Scopus subject areas

  • Genetics

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  • Cite this

    Buermeyer, A. B., Deschênes, S. M., Baker, S. M., & Liskay, R. M. (1999). Mammalian DNA mismatch repair. Annual Review of Genetics, 33, 533-564. https://doi.org/10.1146/annurev.genet.33.1.533