Mammalian bombesin-like peptides

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Mammalian bombesin-like peptides share structural homology with the large family of amphibian bombesin-like peptides. At present there is evidence for two classes of mammalian bombesin-like peptides, the gastrin-releasing peptides (GRP) and the ranatensin-like peptides. GRPs are distributed throughout the mammalian central nervous system, peripheral nervous system, gastrointestinal (GI) tract and the lung where they act as neurotransmitters, autocrine hormones and growth factors. Less is known about the ranatensin-like peptides which to date have been detected only in the brain and spinal cord. The large number of amphibian bombesin-like peptides suggests that still more mammalian bombesin-like peptides remain to be characterized. The challenge will be to determine the key physiological roles of the entire family of these peptides.

Original languageEnglish (US)
Pages (from-to)130-133
Number of pages4
JournalTrends in Neurosciences
Volume9
Issue numberC
DOIs
StatePublished - 1986
Externally publishedYes

Fingerprint

Bombesin
Peptides
Amphibians
Gastrin-Releasing Peptide
Peripheral Nervous System
Neurotransmitter Agents
Gastrointestinal Tract
Spinal Cord
Intercellular Signaling Peptides and Proteins
Central Nervous System
Hormones
Lung
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Mammalian bombesin-like peptides. / Spindel, Eliot.

In: Trends in Neurosciences, Vol. 9, No. C, 1986, p. 130-133.

Research output: Contribution to journalArticle

Spindel, Eliot. / Mammalian bombesin-like peptides. In: Trends in Neurosciences. 1986 ; Vol. 9, No. C. pp. 130-133.
@article{2499dda573d6470a9b6bde0d4bd1fa07,
title = "Mammalian bombesin-like peptides",
abstract = "Mammalian bombesin-like peptides share structural homology with the large family of amphibian bombesin-like peptides. At present there is evidence for two classes of mammalian bombesin-like peptides, the gastrin-releasing peptides (GRP) and the ranatensin-like peptides. GRPs are distributed throughout the mammalian central nervous system, peripheral nervous system, gastrointestinal (GI) tract and the lung where they act as neurotransmitters, autocrine hormones and growth factors. Less is known about the ranatensin-like peptides which to date have been detected only in the brain and spinal cord. The large number of amphibian bombesin-like peptides suggests that still more mammalian bombesin-like peptides remain to be characterized. The challenge will be to determine the key physiological roles of the entire family of these peptides.",
author = "Eliot Spindel",
year = "1986",
doi = "10.1016/0166-2236(86)90042-1",
language = "English (US)",
volume = "9",
pages = "130--133",
journal = "Trends in Neurosciences",
issn = "0378-5912",
publisher = "Elsevier Limited",
number = "C",

}

TY - JOUR

T1 - Mammalian bombesin-like peptides

AU - Spindel, Eliot

PY - 1986

Y1 - 1986

N2 - Mammalian bombesin-like peptides share structural homology with the large family of amphibian bombesin-like peptides. At present there is evidence for two classes of mammalian bombesin-like peptides, the gastrin-releasing peptides (GRP) and the ranatensin-like peptides. GRPs are distributed throughout the mammalian central nervous system, peripheral nervous system, gastrointestinal (GI) tract and the lung where they act as neurotransmitters, autocrine hormones and growth factors. Less is known about the ranatensin-like peptides which to date have been detected only in the brain and spinal cord. The large number of amphibian bombesin-like peptides suggests that still more mammalian bombesin-like peptides remain to be characterized. The challenge will be to determine the key physiological roles of the entire family of these peptides.

AB - Mammalian bombesin-like peptides share structural homology with the large family of amphibian bombesin-like peptides. At present there is evidence for two classes of mammalian bombesin-like peptides, the gastrin-releasing peptides (GRP) and the ranatensin-like peptides. GRPs are distributed throughout the mammalian central nervous system, peripheral nervous system, gastrointestinal (GI) tract and the lung where they act as neurotransmitters, autocrine hormones and growth factors. Less is known about the ranatensin-like peptides which to date have been detected only in the brain and spinal cord. The large number of amphibian bombesin-like peptides suggests that still more mammalian bombesin-like peptides remain to be characterized. The challenge will be to determine the key physiological roles of the entire family of these peptides.

UR - http://www.scopus.com/inward/record.url?scp=0022633004&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022633004&partnerID=8YFLogxK

U2 - 10.1016/0166-2236(86)90042-1

DO - 10.1016/0166-2236(86)90042-1

M3 - Article

VL - 9

SP - 130

EP - 133

JO - Trends in Neurosciences

JF - Trends in Neurosciences

SN - 0378-5912

IS - C

ER -