Abstract
Optic pathway gliomas (OPGs) arise from the optic nerves, optic chiasm, and/or hypothalamus and most commonly occur in childhood. Although these tumors can be quite challenging to manage, they are typically low-grade astrocytomas histologically, most commonly pilocytic astrocytomas. The few previously reported cases of malignant degeneration of an OPG occurred after external beam radiation therapy. The authors report the first case in the English literature of an OPG that transformed from a low-grade astrocytoma, with features most consistent with a pilocytic astrocytoma, to a malignant glioma without any exposure to radiation therapy.
Original language | English (US) |
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Pages (from-to) | 507-510 |
Number of pages | 4 |
Journal | Journal of Neurosurgery: Pediatrics |
Volume | 5 |
Issue number | 5 |
DOIs | |
State | Published - May 2010 |
Externally published | Yes |
Keywords
- Glioblastoma multiforme
- Malignant transformation
- Optic pathway glioma
- Pilocytic astrocytoma
- Radiation therapy
ASJC Scopus subject areas
- Surgery
- Pediatrics, Perinatology, and Child Health
- Clinical Neurology