TY - JOUR
T1 - Malignant pleural mesothelioma and the Society of Thoracic Surgeons Database
T2 - An analysis of surgical morbidity and mortality
AU - Burt, Bryan M.
AU - Cameron, Robert B.
AU - Mollberg, Nathan M.
AU - Kosinski, Andrzej S.
AU - Schipper, Paul H.
AU - Shrager, Joseph B.
AU - Vigneswaran, Wickii T.
PY - 2014/7
Y1 - 2014/7
N2 - Background To date, reported surgical morbidity and mortality for pleurectomy/decortication and extrapleural pneumonectomy performed for malignant pleural mesothelioma primarily represent the experience of a few specialized centers. For comparison, we examined early outcomes of pleurectomy/decortication and extrapleural pneumonectomy from a broader group of centers/surgeons participating in the Society of Thoracic Surgeons-General Thoracic Database. Methods All patients in the Society of Thoracic Surgeons-General Thoracic Database (version 2.081, representing 2009-2011) who underwent pleurectomy/decortication or extrapleural pneumonectomy for malignant pleural mesothelioma were identified. Patient characteristics, morbidity, mortality, center volume, and procedure were examined using univariable and multivariable analyses. Results A total of 225 patients underwent pleurectomy/decortication (n = 130) or extrapleural pneumonectomy (n = 95) for malignant pleural mesothelioma at 48 centers. Higher volumes of procedures (≤5/y) were performed at 3 pleurectomy/decortication and 2 extrapleural pneumonectomy centers. Patient characteristics were statistically equivalent between pleurectomy/decortication and extrapleural pneumonectomy groups, except those undergoing extrapleural pneumonectomy were younger (63.2 ± 7.8 years vs 68.3 ± 9.5 years; P <.001) and more likely to have received preoperative chemotherapy (30.1% vs 17.8%; P =.036). Major morbidity was greater after extrapleural pneumonectomy, including acute respiratory distress syndrome (8.4% vs 0.8%; P =.005), reintubation (14.7% vs 2.3%; P =.001), unexpected reoperation (9.5% vs 1.5%; P =.01), and sepsis (4.2% vs 0%; P =.03), as was mortality (10.5% vs 3.1%; P =.03). Multivariate analyses revealed that extrapleural pneumonectomy was an independent predictor of major morbidity or mortality (odds ratio, 6.51; P =.001). Compared with high-volume centers, increased acute respiratory distress syndrome was seen in low-volume centers performing extrapleural pneumonectomy (0% vs 12.5%; P =.05). Conclusions Extrapleural pneumonectomy is associated with greater morbidity and mortality compared with pleurectomy/decortication when performed by participating surgeons of the Society of Thoracic Surgeons-General Thoracic Database. Effects of center volume require further study.
AB - Background To date, reported surgical morbidity and mortality for pleurectomy/decortication and extrapleural pneumonectomy performed for malignant pleural mesothelioma primarily represent the experience of a few specialized centers. For comparison, we examined early outcomes of pleurectomy/decortication and extrapleural pneumonectomy from a broader group of centers/surgeons participating in the Society of Thoracic Surgeons-General Thoracic Database. Methods All patients in the Society of Thoracic Surgeons-General Thoracic Database (version 2.081, representing 2009-2011) who underwent pleurectomy/decortication or extrapleural pneumonectomy for malignant pleural mesothelioma were identified. Patient characteristics, morbidity, mortality, center volume, and procedure were examined using univariable and multivariable analyses. Results A total of 225 patients underwent pleurectomy/decortication (n = 130) or extrapleural pneumonectomy (n = 95) for malignant pleural mesothelioma at 48 centers. Higher volumes of procedures (≤5/y) were performed at 3 pleurectomy/decortication and 2 extrapleural pneumonectomy centers. Patient characteristics were statistically equivalent between pleurectomy/decortication and extrapleural pneumonectomy groups, except those undergoing extrapleural pneumonectomy were younger (63.2 ± 7.8 years vs 68.3 ± 9.5 years; P <.001) and more likely to have received preoperative chemotherapy (30.1% vs 17.8%; P =.036). Major morbidity was greater after extrapleural pneumonectomy, including acute respiratory distress syndrome (8.4% vs 0.8%; P =.005), reintubation (14.7% vs 2.3%; P =.001), unexpected reoperation (9.5% vs 1.5%; P =.01), and sepsis (4.2% vs 0%; P =.03), as was mortality (10.5% vs 3.1%; P =.03). Multivariate analyses revealed that extrapleural pneumonectomy was an independent predictor of major morbidity or mortality (odds ratio, 6.51; P =.001). Compared with high-volume centers, increased acute respiratory distress syndrome was seen in low-volume centers performing extrapleural pneumonectomy (0% vs 12.5%; P =.05). Conclusions Extrapleural pneumonectomy is associated with greater morbidity and mortality compared with pleurectomy/decortication when performed by participating surgeons of the Society of Thoracic Surgeons-General Thoracic Database. Effects of center volume require further study.
UR - http://www.scopus.com/inward/record.url?scp=84902549356&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84902549356&partnerID=8YFLogxK
U2 - 10.1016/j.jtcvs.2014.03.011
DO - 10.1016/j.jtcvs.2014.03.011
M3 - Article
C2 - 24726744
AN - SCOPUS:84902549356
SN - 0022-5223
VL - 148
SP - 30
EP - 35
JO - Journal of Thoracic and Cardiovascular Surgery
JF - Journal of Thoracic and Cardiovascular Surgery
IS - 1
ER -