Malignant hyperthermia of anesthesia

Bruce Wolfe, L. W. Gaston, R. M. Keltner

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Malignant hyperthermia of anesthesia generally occurs in otherwise healthy subjects and carries a high mortality. It is characterized by rapid elevation in body temperature, muscular rigidity, ventricular arrhythmias, acidosis, and cardiovascular collapse. Successful management is dependent on immediate diagnosis, discontinuation of anesthesia, hyperventilation, cooling, and appropriate drugs. Several cases of hemorrhage secondary to disseminated intravascular coagulation have been reported, and routine heparinization is recommended while appropriate laboratory studies are carried out. Two cases of malignant hyperthermia of anesthesia are reported. In the first case diffuse hemorrhage secondary to disseminated intravascular coagulation played a significant role in the patient's death. In the second case prompt therapeutic maneuvers, including the use of procaine, led to eventual recovery.

Original languageEnglish (US)
Pages (from-to)717-721
Number of pages5
JournalThe American Journal of Surgery
Volume126
Issue number6
DOIs
StatePublished - 1973
Externally publishedYes

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Malignant Hyperthermia
Disseminated Intravascular Coagulation
Hemorrhage
Muscle Rigidity
Procaine
Hyperventilation
Acidosis
Body Temperature
Cardiac Arrhythmias
Healthy Volunteers
Anesthesia
Mortality
Pharmaceutical Preparations
Therapeutics

ASJC Scopus subject areas

  • Surgery

Cite this

Malignant hyperthermia of anesthesia. / Wolfe, Bruce; Gaston, L. W.; Keltner, R. M.

In: The American Journal of Surgery, Vol. 126, No. 6, 1973, p. 717-721.

Research output: Contribution to journalArticle

Wolfe, Bruce ; Gaston, L. W. ; Keltner, R. M. / Malignant hyperthermia of anesthesia. In: The American Journal of Surgery. 1973 ; Vol. 126, No. 6. pp. 717-721.
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